Optical paper-based sensor for ascorbic acid quantification using silver nanoparticles

Autor(es)

Melo Ferreira, Danielle Cristhina ^[1] ; Giordano, Gabriela Furlan ^[1] ; dos Santos Penteado Soares, Caio Cesar ^[1] ; Afonso de Oliveira, Jessica Fernanda ^{[2, 3]} ; Mendes, Renata Kelly ^[4] ; Piazzetta, Maria Helena ^[1] ; Gobbi, Angelo Luiz ^[1] ; Cardoso, Mateus Borba ^{[2, 3]}

Afiliação do(s) autor(es)

^[1] Ctr Nacl Pesquisa Energia & Mat, LNNano Lab Nacl Nanotecnol, BR-13083970 Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Inst Quim, BR-13083970 Sao Paulo - Brazil

^[3] Ctr Nacl Pesquisa Energia & Mat, LNLS, BR-13083970 Sao Paulo - Brazil

^[4] Pontificia Univ Catolica Campinas, Fac Quim, BR-13012970 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Talanta; v. 141, p. 188-194, AUG 15 2015.
• Citações Web of Science: 34

Resumo

In this paper, we demonstrate for the first time the use of silver nanoparticles (AgNPs) for colorimetric ascorbic acid (AA) quantification in a paper-based sensor. This device is constituted by spot tests modified with AgNPs and silver ions bordered by a hydrophobic barrier which provides quantitative and fast analysis of AA. In addition, this device is employed as point-of-care monitoring using a unique drop of the sample. AgNPs paper-based sensor changed from light yellow to gray color after the addition of AA due to nanoparticle growth and clusters formation. The color intensities were altered as a function of AA concentration which were measured by either a scanner or a homemade portable transmittance colorimeter. Under the selected measurement conditions, results presented limit of detection which was comparable to analytical laboratory-based methodologies. In addition, the sensitivity of our sensor was comparable to the standard titration method when real samples were investigated. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 11/21954-7 - Funcionalização de nanopartículas compósitas para aplicações biomédicas
• Beneficiário: Mateus Borba Cardoso
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/22429-9 - Síntese de nanopartículas de sílica mesoporosa funcionalizadas com anticorpos monoclonais: uma alternativa para o tratamento de linfomas Hodgkin (LH) e linfoma anaplásico de grandes células CD30+ (ALCL - CD30+)
• Beneficiário: Jessica Fernanda Affonso de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado