| Texto completo | |
| Autor(es): Mostrar menos - |
Ataide, Ricardo
[1, 2]
;
Murillo, Oscar
[1]
;
Dombrowski, Jamille G.
[1]
;
Souza, Rodrigo M.
[1, 3]
;
Lima, Flavia A.
[1]
;
Lima, Giselle F. M. C.
[4]
;
Hristov, Angelica D.
[4]
;
Valle, Suiane C. N.
[3]
;
Di Santi, Silvia M.
[4]
;
Epiphanio, Sabrina
[5]
;
Marinho, Claudio R. F.
[1]
Número total de Autores: 11
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo ICB USP, Dept Parasitol, Sao Paulo, SP - Brazil
[2] Burnet Inst, Ctr Biomed Res, Melbourne - Australia
[3] Univ Fed Acre, Ctr Multidisciplinar, Cruzeiro Do Sul, Acre - Brazil
[4] Univ Sao Paulo, Nucleo Estudos Malaria, Superintendencia Controle Endemias, Inst Med Trop Sao Paulo IMT, BR-09500900 Sao Paulo, SP - Brazil
[5] Univ Sao Paulo FCF USP, Dept Anal Clin & Toxicol, Sao Paulo, SP - Brazil
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PLoS Neglected Tropical Diseases; v. 9, n. 6 JUN 2015. |
| Citações Web of Science: | 10 |
| Resumo | |
Malaria in pregnancy remains a substantial public health problem in malaria-endemic areas with detrimental outcomes for both the mother and the foetus. The placental changes that lead to some of these detrimental outcomes have been studied, but the mechanisms that lead to these changes are still not fully elucidated. There is some indication that imbalances in cytokine cascades, complement activation and angiogenic dysregulation might be involved in the placental changes observed. Nevertheless, the majority of studies on malaria in pregnancy (MiP) have come from areas where malaria transmission is high and usually restricted to Plasmodium falciparum, the most pathogenic of the malaria parasite species. We conducted a cross-sectional study in Cruzeiro do Sul, Acre state, Brazil, an area of low transmission and where both P. vivax and P. falciparum circulate. We collected peripheral and placental blood and placental biopsies, at delivery from 137 primigravid women and measured levels of the angiogenic factors angiopoietin (Ang)-1, Ang-2, their receptor Tie-2, and several cytokines and chemokines. We measured 4 placental parameters (placental weight, syncytial knots, placental barrier thickness and mononuclear cells) and associated these with the levels of angiogenic factors and cytokines. In this study, MiP was not associated with severe outcomes. An increased ratio of peripheral Tie-2: Ang-1 was associated with the occurrence of MiP. Both Ang-1 and Ang-2 had similar magnitudes but inverse associations with placental barrier thickness. Malaria in pregnancy is an effect modifier of the association between Ang-1 and placental barrier thickness. (AU) | |
| Processo FAPESP: | 12/04755-3 - Associação entre malária gestacional, restrição do crescimento intrauterino e baixo peso ao nascer na Amazônia Extremo-Ocidental Brasileira |
| Beneficiário: | Jamille Gregório Dombrowski |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 09/53256-7 - Identificação e caracterização da síndrome respiratória aguda murina associada à malária severa: estudo da interação parasito-hospedeiro |
| Beneficiário: | Sabrina Epiphanio |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 09/53889-0 - Estudo dos mecanismos imunopatológicos envolvidos na malária durante a gravidez |
| Beneficiário: | Cláudio Romero Farias Marinho |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 11/20921-8 - Malária gestacional: Estudo da infecção por Plasmodium vivax em gestantes do extremo-ocidente da Amazônia brasileira |
| Beneficiário: | Ricardo Tenreiro Estiveira de Ataide |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |