Anthelmintic Effects of the Essential Oil of Fennel (Foeniculum vulgare Mill., Apiaceae) against Schistosoma mansoni

Autor(es):Mostrar menos -

Wakabayashi, Kamila A. L. ^[1] ; de Melo, Nathalya I. ^[1] ; Aguiar, Daniela P. ^[1] ; de Oliveira, Pollyanna F. ^[1] ; Groppo, Milton ^[2] ; da Silva Filho, Ademar A. ^[3] ; Rodrigues, Vanderlei ^[4] ; Cunha, Wilson R. ^[1] ; Tavares, Denise C. ^[1] ; Magalhaes, Lizandra G. ^[1] ; Crotti, Antonio E. M. ^{[5, 1]}

Afiliação do(s) autor(es)

^[1] Univ Franca, Nucleo Pesquisas Ciencias Exatas & Tecnol, Franca, SP - Brazil

^[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Biol, BR-14049 Ribeirao Preto, SP - Brazil

^[3] Univ Fed Juiz de Fora, Fac Farm, Juiz De Fora, MG - Brazil

^[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, BR-14049 Ribeirao Preto, SP - Brazil

^[5] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14049 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CHEMISTRY & BIODIVERSITY; v. 12, n. 7, p. 1105-1114, JUL 2015.
• Citações Web of Science: 11

Resumo

Foeniculum vulgareMill. (Apiaceae), known as fennel, is a widespread aromatic herbaceous plant, and its essential oil is used as additive in the food, pharmaceutical, cosmetic, and perfume industries. The in vitro antischistosomal activity and cytotoxic effects against V79 cells of the essential oil of F. vulgare cultivated in southeastern Brazil (FV-EO) was investigated. The FV-EO was obtained by hydrodistillation and characterized by GC-FID and GC/MS analyses. (E)-Anethole (69.8%) and limonene (22.5%) were identified as the major constituents. Its anthelmintic activity against Schistosoma mansoni was evaluated at concentrations of 10, 50, and 100g/ml, and it was found to be active against adult S. mansoni worms, although it was less effective than the positive control praziquantel (PZQ) in terms of separation of the coupled pairs, mortality, and decreased motor activity. However, FV-EO elicited an interesting dose-dependent reduction in the number of S. mansoni eggs. On their own, (E)-anethole and the limonene enantiomers were much less effective than FV-EO and PZQ. An XTT-cytotoxicity-based assay evidenced no FV-EO cytotoxicity against V79 cells. In summary, FV-EO displayed moderate in vitro schistosomicidal activity against adult S. mansoni worms, exerted remarkable inhibitory effects on the egg development, and was of low toxicity. (AU)

• Processo FAPESP: 11/05732-4 - Estudo do potencial citotóxico e genotóxico do extrato de Solanum lycocarpum e dos seus compostos majoritários e sua influência sobre a genotoxicidade induzida por diferentes mutágenos
• Beneficiário: Denise Crispim Tavares
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/54241-8 - Prospecção de óleos essenciais de espécies brasileiras cultiváveis com atividade contra patógenos da cavidade bucal
• Beneficiário: Antônio Eduardo Miller Crotti
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Jovens Pesquisadores
• Processo FAPESP: 09/15207-4 - Avaliação do efeito de lignanas e neolignanas em Schistosoma mansoni: uma abordagem proteômica
• Beneficiário: Lizandra Guidi Magalhães
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado