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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Higher Cardiovascular Risk in Common Variable Immunodeficiency and X-Linked Agammaglobulinaemia Patients

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Autor(es):
Vieira, Daniele Goncalves [1, 2] ; Costa-Carvalho, Beatriz Tavares [1] ; Hix, Sonia [3] ; da Silva, Rosangela [4] ; Correia, Milena S. G. [3] ; Saccardo Sarni, Roseli Oselka [1, 3]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Sao Paulo, SP - Brazil
[2] Midwest State Univ, Guarapuava, Parana - Brazil
[3] ABC Univ, Santo Andre, SP - Brazil
[4] Univ Fed Alfenas, Alfenas, MG - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: ANNALS OF NUTRITION AND METABOLISM; v. 66, n. 4, p. 237-241, 2015.
Citações Web of Science: 3
Resumo

Introduction: Common variable immunodeficiency and X-linked agammaglobulinaemia are primary immunodeficiencies classified as antibody deficiencies, and they both result in hypogammaglobulinaemia. Objective: Evaluate the lipid profile and other cardiovascular risk biomarkers in CVID and XLA patients. Methods: In total, 24 patients and 12 healthy controls matched by age and gender were included in the study. We evaluated anthropometric measurements, and seric total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), apo A-I, small dense LDL (sdLDL), C-reactive protein (CRP), and tumour necrosis factor alpha (TNF-alpha), myeloperoxidase (MPO), cholesteryl ester transfer protein (CETP), and lecithin cholesterol acyltransferase (LCAT) were assessed. Results: CRP (p = 0.008) and TNF-alpha (p < 0.001) concentrations were significantly higher, whereas HDL-c (p = 0.025) and apo A-I (p = 0.013) levels were significantly lower in patients than in the controls. In the patient group, a negative and significant correlation was observed between HDL-c and TNF-alpha (r = -0.406; p = 0.049) and between HDL-c and TG (r = -0.641; p = 0.001). Conclusion: Common variable immunodeficiency and X-linked agammaglobulinaemia patients presented themselves with increased inflammatory markers associated with a decreased HDL-c and apo A-I levels, which can predispose to a high cardiovascular risk. (C) 2015 S. Karger AG, Basel (AU)

Processo FAPESP: 11/13336-1 - Avaliação do perfil lipídico e das apoliproteínas A1 e B: relação com enzimas associadas ao risco cardiovascular em pacientes com hipogamaglobulinemia
Beneficiário:Roseli Oselka Saccardo Sarni
Linha de fomento: Auxílio à Pesquisa - Regular