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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Influence of Melatonin on the Proliferative and Apoptotic Responses of the Prostate under Normal and Hyperglycemic Conditions

Texto completo
Autor(es):
Gobbo, Marina G. [1] ; Dizeyi, Nishtman [2] ; Abrahamsson, Per-Anders [2] ; Bertilsson, Per-Anders [2] ; Masiteli, Viviane Sanches [3] ; Pytlowanciv, Eloisa Zanin [1] ; Taboga, Sebastiao R. [3] ; Goes, Rejane M. [3]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Inst Biol, Dept Cell Biol, Campinas, SP - Brazil
[2] Lund Univ, Skane Univ Hosp, Div Urol Res, Dept Clin Sci, S-20502 Malmo - Sweden
[3] UNESP, Inst Biosci Humanities & Exact Sci, Dept Biol, Sao Jose Do Rio Preto, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF DIABETES RESEARCH; 2015.
Citações Web of Science: 11
Resumo

The antitumor properties of melatonin (MLT) are known for prostate cancer cells. This study investigated whether MLT affects prostate maturation and interferes with tissue injuries induced by diabetes. MLT was administered to Wistar rats from 5 weeks of age in the drinking water (10 mu g/kg b.w.), and diabetes was induced at the 13th week by streptozotocin (4.5 mg/100g b.w., i.p.). The animals were euthanized in the 14th and 21st weeks. MLT reduced the immunostained cells for androgen receptor (AR) by 10% in younger rats. Diabetes decreased cell proliferation and increased apoptosis. MLT treatment impeded apoptosis (P = 0.02) and augmented proliferation (P = 0.0008) and PCNA content in prostate following long-term diabetes due to restoration of testosterone levels and expression of melatonin receptor type 1B. The effect of MLT (500 mu M, 5 mM, and 10 mM) on androgen-dependent (22Rv1) and androgen-independent (PC3) cancer cells and human prostate epithelial cells (PNTA1) under normal and hyperglycemic conditions (HG, 450 mg/dL) was analyzed. Contrary to PNTA1 and 22Rv1 cells, MLT improved the proliferation of PC3 cells in hyperglycemic medium. The combined data indicated that MLT had proliferative and antiapoptotic effects in prostate cells subjected to HG levels and it seems to involve specific MLT pathways rather than AR. (AU)

Processo FAPESP: 11/19467-0 - Administração de melatonina durante a maturação sexual: influência na histofisiologia da próstata adulta e papel protetor contra os danos causados pelo diabetes experimental
Beneficiário:Marina Guimarães Gobbo
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 14/07266-9 - Os efeitos da melatonina nas células prostáticas cancerígenas dependentes e independentes de andrógenos em condições hiperglicêmicas
Beneficiário:Marina Guimarães Gobbo
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado