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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Prenatal exposure to testosterone masculinises the female gerbil and promotes the development of lesions in the prostate (Skene's gland)

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Autor(es):
Biancardi, Manoel F. [1] ; Perez, Ana P. S. [1] ; Suzuki Caires, Cassia Regina [2] ; Goes, Rejane M. [2] ; Vilamaior, Patricia S. L. [2] ; Santos, Fernanda C. A. [3] ; Taboga, Sebastiao R. [2, 1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Dept Struct & Funct Biol, BR-13084864 Campinas, SP - Brazil
[2] Univ Estadual Paulista UNESP, Dept Biol, Lab Microscopy & Microanal, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[3] Univ Fed Goias, Dept Morphol, BR-74001970 Goiania, Go - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: REPRODUCTION FERTILITY AND DEVELOPMENT; v. 27, n. 7, p. 1000-1011, 2015.
Citações Web of Science: 10
Resumo

Androgenic imbalance may disrupt prostate development, leading to morphological alterations in adulthood and predisposing this gland to develop diseases during ageing. However, little is known about the endocrine disruption of the prostate that is caused by androgenic compounds, especially in female experimental models. Therefore, this study aimed to evaluate the prostates of aged female gerbils exposed to testosterone at certain periods in intrauterine and postnatal life, to determine whether exposure at a particular age increases susceptibility to prostatic lesions in these animals. To this end, morphological, stereological, immunohistochemical and immunofluorescence analyses were employed. It was found that females exposed to testosterone during intrauterine life were masculinised, showing increased anogenital distance, absence of the vaginal opening and ectopic development of prostatic tissue. Several areas of adenomatous hyperplasia, generally associated with inflammatory foci and mainly located in the ectopic prostatic tissue around the vaginal wall, were also observed. In conclusion, the results showed that abnormal prenatal exposure to testosterone severely affects the reproductive systems of female animals by disrupting normal prostate morphogenesis and increasing susceptibility to the development of prostatic diseases during ageing. (AU)

Processo FAPESP: 09/16789-7 - Efeitos da exposição intra-uterina e puberal do cipionato de testosterona sobre a próstata de machos e fêmeas de gerbilos senis
Beneficiário:Manoel Francisco Biancardi
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 09/53990-2 - EMU: aquisição de microscópio de varredura confocal a laser para um centro multiusuário de microscopia da UNESP
Beneficiário:Sebastião Roberto Taboga
Linha de fomento: Auxílio à Pesquisa - Programa Equipamentos Multiusuários