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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Intake of Passiflora edulis leaf extract improves antioxidant and anti-inflammatory status in rats with 2,4,6-trinitrobenzenesulphonic acid induced colitis

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Autor(es):
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Betim Cazarin, Cinthia Bau [1] ; da Silva, Juliana Kelly [1] ; Colomeu, Talita Cristina [2] ; Batista, Angela Giovana [1] ; Molina Meletti, Laura Maria [3] ; Rizzato Paschoal, Jonas Augusto [1] ; Bogusz Junior, Stanislau [4] ; de Campos Braga, Patricia Aparecida [1] ; Reyes Reyes, Felix Guillermo [1] ; Augusto, Fabio [5] ; de Meirelles, Luciana Rodrigues [2] ; Zollner, Ricardo de Lima [2] ; Marostica Junior, Mario Roberto [1]
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Sch Food Engn, Sao Paulo - Brazil
[2] Univ Estadual Campinas, Fac Med Sci, Sao Paulo - Brazil
[3] Agron Inst Campinas, Ctr Res & Dev Plant Genet Resources, Campinas, SP - Brazil
[4] Univ Sao Paulo, Inst Chem Sao Carlos IQSC, Sao Paulo - Brazil
[5] Univ Estadual Campinas, Inst Chem, Inst Nacl Ciencia & Tecnol Bioanalit INCTBio, Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Journal of Functional Foods; v. 17, p. 575-586, AUG 2015.
Citações Web of Science: 8
Resumo

The antioxidant and anti-inflammatory effects of the aqueous extract of Passiflora edulis leaves, which is a source of vitexin, isovitexin and isoorientin, was investigated in a 2,4,6-trinitrobenzenesulphonic acid induced colitis model. The oral intake of P. edulis extract (1100 mu g mL(-1)) improved significantly (P < 0.05) the endogenous antioxidant status and decreased lipid peroxidation in serum, liver, and colon. The consumption of P. edulis extract decreased the level of pro-inflammatory in colon tissue, especially by reducing IL-1 beta fivefold and TNF-alpha two-fold compared to the control colitis group. The extract of P. edulis leaves possessed therapeutic activity in healthy rats and in TNBS-induced colitis, especially by controlling the oxidative stress and inflammation observed in this disease. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 10/16752-3 - Avaliação do consumo da casca de Passiflora edulis e seu impacto na inflamação intestinal de ratos com colite ulcerativa
Beneficiário:Cinthia Baú Betim Cazarin
Linha de fomento: Bolsas no Brasil - Doutorado