Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Efficacy and Safety of 2% and 4% Articaine for Lower Third Molar Surgery

Texto completo
Autor(es):
Senes, A. M. [1] ; Calvo, A. M. [1] ; Colombini-Ishikiriama, B. L. [1] ; Goncalves, P. Z. [1] ; Dionisio, T. J. [1] ; Sant'ana, E. [1] ; Brozoski, D. T. [1] ; Lauris, J. R. P. [1] ; Faria, F. A. C. [1] ; Santos, C. F. [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Bauru Sch Dent, Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF DENTAL RESEARCH; v. 94, n. 9, 2, p. 166S-173S, SEP 2015.
Citações Web of Science: 9
Resumo

This double-blind crossover randomized clinical trial compared the efficacy of 2 concentrations of articaine, 2% (A2) and 4% (A4), with 1:200,000 epinephrine, for lower third molar removal. During 2 separate appointments with either A2 or A4, both similarly positioned lower third molars in 46 volunteers were extracted. The following were evaluated: onset and duration of anesthetic action on soft tissues, intraoperative bleeding, hemodynamic parameters, postoperative analgesia, and mouth opening and wound healing during the 7th postoperative day, along with the incidence, type, and severity of adverse reactions. Nearly identical volumes of both anesthetic solutions were used for each appointment: 3.4 +/- 0.9 mL approximate to 68 mg of articaine (A2) and 3.3 +/- 0.8 mL approximate to 132 mg of articaine (A4). Statistical analysis indicated no differences in onset or duration of anesthetic action on soft tissues or duration of postoperative analgesia evoked by A2 and A4 anesthetic solutions (P > 0.05). The surgeon's rating of intraoperative bleeding was considered minimal throughout all surgery with both anesthetic solutions. While transient changes in blood pressure, heart rate, and oxygen saturation were observed, these factors were clinically insignificant and were uninfluenced by articaine concentration (P > 0.05). No systemic or local adverse reactions were observed in the preoperative and postoperative periods due to A2 or A4, but 1 case of bilateral paresthesia was observed. There were no significant differences between preoperative and postoperative (7th day) values of mouth opening and wound healing whether volunteers received A2 or A4 (P > 0.05). In conclusion, both A2 and A4, administered in equal volumes, were effective and safe during lower third molar surgery, and no significant differences were found between their efficacy and safety (ClinicalTrials.gov NCT02457325). (AU)

Processo FAPESP: 09/17851-8 - Influência do genótipo do citocromo P450 (CYP2C9) na eficácia clínica e farmacocinética do piroxicam após cirurgias de terceiros molares inferiores
Beneficiário:Adriana Maria Calvo
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 09/15372-5 - Interação entre o sistema renina-angiotensina e o fator de crescimento endotelial na doença periodontal induzida experimentalmente em ratos
Beneficiário:Daniel Thomas Brozoski
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 10/16985-8 - 1) Análise comparativa entre articaína 2% e articaína 4% ambas com adrenalina 1:200.000: avaliação da eficácia anestésica, sangramento intra-operatório e parâmetros hemodinâmicos em exodontias de terceiros molares inferiores, e 2) Avaliação da eficácia clínica do piroxicam administrado por via oral e sublingual para o controle da dor, edema e trismo após exodontia de terceiros molares inferiores
Beneficiário:Carlos Ferreira dos Santos
Modalidade de apoio: Auxílio à Pesquisa - Regular