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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula

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Autor(es):
Garcia-Cordero, Indira [1] ; Sedeno, Lucas [1, 2, 3] ; Fraiman, Daniel [3, 4] ; Craiem, Damian [3, 5] ; Alethia de la Fuente, Laura [1] ; Salamone, Paula [1] ; Serrano, Cecilia [6] ; Sposato, Luciano [7] ; Manes, Facundo [1, 2, 3, 8] ; Ibanez, Agustin [1, 2, 3, 8, 9]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Favaloro Univ, Inst Cognit Neurol INECO, Lab Expt Psychol & Neurosci LPEN, Buenos Aires, DF - Argentina
[2] Diego Portales Univ, Fac Psychol, UDP INECO Fdn Core Neurosci UIFCoN, Santiago - Chile
[3] Natl Sci & Tech Res Council CONICET, Buenos Aires, DF - Argentina
[4] Univ San Andres, Lab Invest Neurociencia, Buenos Aires, DF - Argentina
[5] Univ Favaloro, Fac Ingn Ciencias Exactas & Nat, Buenos Aires, DF - Argentina
[6] Memory & Balance Clin, Buenos Aires, DF - Argentina
[7] Univ Western Ontario, Dept Clin Neurol Sci, London, ON - Canada
[8] ACR Ctr Excellence Cognit & Its Disorders, Sydney, NSW - Australia
[9] Univ Autonoma Caribe, Barranquilla - Colombia
Número total de Afiliações: 9
Tipo de documento: Artigo Científico
Fonte: STROKE; v. 46, n. 9, p. 2673-2677, SEP 2015.
Citações Web of Science: 22
Resumo

Background and Purpose-Stroke and neurodegeneration cause significant brain damage and cognitive impairment, especially if the insular cortex is compromised. This study explores for the first time whether these 2 causes differentially alter connectivity patterns in the insular cortex. Methods-Resting state-functional magnetic resonance imaging data were collected from patients with insular stroke, patients with behavioral variant frontotemporal dementia, and healthy controls. Data from the 3 groups were assessed through a correlation function analysis. Specifically, we compared decreases in connectivity as a function of voxel Euclidean distance within the insular cortex. Results-Relative to controls, patients with stroke showed faster connectivity decays as a function of distance (hypoconnectivity). In contrast, the behavioral variant frontotemporal dementia group exhibited significant hyperconnectivity between neighboring voxels. Both patient groups evinced global hypoconnectivity. No between-group differences were observed in a volumetrically and functionally comparable region without ischemia or neurodegeneration. Conclusions-Functional insular cortex connectivity is affected differently by cerebral ischemia and neurodegeneration, possibly because of differences in the cause-specific pathophysiological mechanisms of each disease. These findings have important clinical and theoretical implications. (AU)

Processo FAPESP: 13/07699-0 - Centro de Pesquisa, Inovação e Difusão em Neuromatemática - NeuroMat
Beneficiário:Jefferson Antonio Galves
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs