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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Clinicopathological and immunohistochemical evaluation of oesophageal leiomyosarcoma in a dog

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Autor(es):
Ciccone Alves, Renata Cintra [1] ; Batista, Tatiana Linardi [1] ; Laufer-Amorim, Renee [2] ; Elias, Fabiana [3] ; Calazans, Sabryna Gouveia [4] ; Fonseca-Alves, Carlos Eduardo [5]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Fac Jaguariuna FAJ, Programa Posgrad Oncol Vet, Jaguariuna, SP - Brazil
[2] Univ Estadual Paulista UNESP, FMVZ, BR-18609020 Botucatu, SP - Brazil
[3] UFFS, Realeza, PR - Brazil
[4] Univ Fed Franca UNIFRAN, Dept Vet Med, Franca, SP - Brazil
[5] Univ Estadual Paulista UNESP, Programa Posgrad Med Vet, BR-18609020 Botucatu, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Ciência Rural; v. 45, n. 9, p. 1644-1647, SEP 2015.
Citações Web of Science: 1
Resumo

Oesophageal leiomyosarcoma is a malignant neoplasm of smooth muscle fibres that is infrequently reported in the literature. Because of the importance of definitive diagnosis and the low incidence of this tumour in dogs, it was reported a case of oesophageal leiomyosarcoma in a dog. A 13-year-old intact male Rottweiler presented regurgitation, hyporexia, and chronic weight loss. After an imaging examination, tumour in the thoracic oesophagus was suspected and a biopsy was sugested for definitive diagnosis. However, the owner did not permit the procedure. Six months after the clinical diagnosis, the patient was brought for evaluation of anorexia, apathy, and severe dyspnoea. Because of the patient's clinical signs and lack of response to emergency treatment, he was euthanized. Upon necropsy, it was identified the neoplastic formation, previously identified in the radiographic examination in the thoracic oesophagus, near the diaphragm. Histopathology revealed a proliferation of mesenchymal cells, and the diagnosis of leiomyosarcoma was confirmed by immunohistochemical examination. Despite the low incidence of oesophageal leiomyosarcoma, it should be included as a differential diagnosis for animals with chronic regurgitation. (AU)

Processo FAPESP: 12/18426-1 - Avaliação epigenética dos genes NKX3.1 e CDH1 e expressão do c-Myc, NKX3.1 e caderina-E por imunoistoquímica em microarranjo de tecido (TMA) de lesões pré-neoplásicas e neoplásicas na próstata de cães
Beneficiário:Carlos Eduardo Fonseca Alves
Linha de fomento: Bolsas no Brasil - Doutorado