Oral Administration of Aloe vera (L.) Burm. f. (Xanthorrhoeaceae) and Honey Improves the Host Body Composition and Modulates Proteolysis Through Reduction of Tumor Progression and Oxidative Stress in Rats

Autor(es)

Tomasin, Rebeka ^[1] ; de Andrade, Rafael Siqueira ^[1] ; Cintra Gomes-Marcondes, Maria Cristina ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Lab Nutr & Canc, Dept Struct & Funct Biol, Inst Biol, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF MEDICINAL FOOD; v. 18, n. 10, p. 1128-1135, OCT 1 2015.
• Citações Web of Science: 3

Resumo

Oxidative stress has a dual role in cancer; it is linked with tumorigenic events and host wasting, as well as senescence and apoptosis. Researchers have demonstrated the importance of coadjuvant therapies in cancer treatment, and Aloe vera and honey have immunomodulatory, anticancer, and antioxidant properties. The preventive and therapeutic effects of Aloe vera (L.) Burm. f. (Xanthorrhoeaceae) and honey in tumor progression and host wasting were analyzed in Walker 256 carcinoma-bearing rats. The animals were distributed into the following groups: C=control-untreated, W=tumor-untreated, WA=treated after tumor induction, A=control-treated, AW=treated before tumor induction, and AWA=treated before and after tumor induction. Proteolysis and oxidative stress were analyzed in the tumor, liver, muscle, and myocardial tissues. The results suggest that the Aloe vera and honey treatment affect the tumor and host by different mechanisms; the treatment-modulated host wasting and cachexia, whereas it promoted oxidative stress and damage in tumor tissues, particularly in a therapeutic context (WA). (AU)

• Processo FAPESP: 13/16115-1 - Estudo dos mecanismos bioquímicos e moleculares da caquexia: avaliação dos efeitos do fator Walker (FW) e da leucina em cultura celular de miotúbulos (células C2C12)
• Beneficiário: Maria Cristina Cintra Gomes Marcondes
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/05788-4 - Efeitos preventivos e terapêuticos do homogeneizado de Aloe vera e mel sobre o crescimento e atividade celular do carcinossarcoma de Walker 256 in vivo e in vitro
• Beneficiário: Rebeka Tomasin
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 10/00209-9 - Nutrição e câncer estudo das alterações metabólicas e moleculares do metabolismo protéico no câncer-caquexia, moduladas pela suplementação nutricional com leucina, no crescimento, desenvolvimento e gravidez
• Beneficiário: Maria Cristina Cintra Gomes Marcondes
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/00714-5 - "Estudo dos Efeitos Modulatórios da Aloe vera e mel sobre o crescimento tumoral"
• Beneficiário: Rebeka Tomasin
• Modalidade de apoio: Bolsas no Brasil - Doutorado