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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Allele substitution effects of IGF1, GH and PIT1 markers on estimated breeding values for weight and reproduction traits in Canchim beef cattle

Texto completo
Autor(es):
Grossi, Daniela do Amaral [1] ; Grupioni, Natalia Vinhal [2] ; Buzanskas, Marcos Eli [2] ; Paro de Paz, Claudia Cristina [3, 4] ; de Almeida Regitano, Luciana Correia [5] ; de Alencar, Mauricio Mello [5] ; Schenkel, Flavio Schramm [1] ; Munari, Danisio Prado [2]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Guelph, Dept Anim & Poultry Sci, Ctr Genet Improvement Livestock, Guelph, ON N1G 2W1 - Canada
[2] UNESP Univ Estadual Paulista, Fac Ciencias Agr & Vet, Dept Ciencias Exatas, BR-14884900 Jaboticabal, SP - Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Genet, BR-14049900 Ribeirao Preto, SP - Brazil
[4] Ctr APTA Bovinos Corte, Inst Zootecnia, BR-14174000 Sertaozinho, SP - Brazil
[5] EMBRAPA Pecuaria Sudeste, Empresa Brasileira Pesquisa Agr, BR-13560970 Sao Carlos, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: LIVESTOCK SCIENCE; v. 180, p. 78-83, OCT 2015.
Citações Web of Science: 1
Resumo

The aim of this study was to evaluate the allele substitution effects of IGF1, GH and PIT1 markers on the estimated breeding values (EBVs) for birth (BW) and weaning weights (WW), weight at 12 (W12) and 18 (W18) months of age, weight (WFC) and age (AFC) at first calving, and scrotal circumference measured at 12 (SC12) and 18 (SC18) months of age in Canchim beef cattle. Maternal effects were considered for birth (BWmaternal) and weaning (WWmaternal) weight Regression analyses were carried out considering the EBVs, obtained from multi-trait analyses, and the deviations for each allele studied (four alleles for the IGF1 markers and two for GH and PIT1 markers, respectively). According to the results obtained for IGF1, the substitution effect of the ``225{''} allele was significant (P <= 0.05) and presented higher EBVs for BW, BWmaternal, WW, W12, W18, and SC18; and lower EBVs for WWmaternal. The allele substitution effect observed for GH gene was significant (P <= 0.05) on EBVs for AFC and WFC. The ``Valine{''} allele was responsible for lower EBVs for AFC and higher EBVs for WFC. For the PIT1 gene, the substitution effect of the ``Hinf -{''} allele was significant (P <= 0.05) on the EBVs for WW, WWmaternal, AFC, and WFC, respectively. Important allele substitution effects were found for weight and reproduction traits in Canchim cattle. In general, markers on the IGF1 gene are related to higher EBVs for weight, while markers on the GH and PIT1 showed greater influence on the EBVs for age and weight at first calving. Adding molecular markers information on the selection process could result in increased genetic gains in Canchim cattle. Future studies using high-density genotyping platforms may contribute to our understanding of the effects of these genes on traits of economic importance in the Canchim breed. (C) 2015 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 08/09393-7 - Associação dos genes do fator do crescimento semelhante à insulina tipo 1, do hormônio do crescimento e do fator de transcrição da pituitária com valores genéticos de idade e peso corporal ao primeiro parto de fêmeas Canchim
Beneficiário:Natalia Vinhal Grupioni
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 13/19335-2 - Estudo do nível de mistura em animais da raça Canchim e grupo genético ma utilizando painel de polimorfismos de nucleotídeo único de alta densidade
Beneficiário:Marcos Eli Buzanskas
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 06/60043-1 - Efeito de marcadores moleculares sobre as caracteristicas de crescimento e reprodutivas de bovinos da raca canchim.
Beneficiário:Daniela Do Amaral Grossi
Linha de fomento: Bolsas no Brasil - Doutorado