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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

B-1 cells contribute to susceptibility in experimental infection with Leishmania (Leishmania) chagasi

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Autor(es):
Kennerly Marcondes Gonzaga, Wagner Francisco [1] ; Xavier, Vanessa [2] ; Vivanco, Bruno Camolese [1] ; Lopes, Jose Daniel [1, 3] ; Xander, Patricia [2]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Microbiol Imunol & Parasitol, BR-04023900 Diadema - Brazil
[2] Univ Fed Sao Paulo, Dept Ciencias Biol, BR-04023900 Diadema - Brazil
[3] Univ Fed Sao Paulo, BR-04023900 Diadema - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Parasitology; v. 142, n. 12, p. 1506-1515, OCT 2015.
Citações Web of Science: 10
Resumo

The immune response to leishmaniasis is complex, and the result of infection depends on both the genetic composition of the Leishmania species and the immunity of the host. Clinical and experimental evidence suggest that the activation of B cells leads to exacerbation of visceral leishmaniasis. However, the role of B-1 cells (a subtype of B lymphocytes) in the pathogenesis of experimental visceral leishmaniasis has not yet been elucidated. In this study, we investigated the importance of B-1 cells in experimental infection with Leishmania. (L.) chagasi. Our results showed that BALB/XID mice (X-linked immunodeficient mice which are genetically deficient in B-1 cells) infected with L. (L.) chagasi for 45 days had a significant reduction in parasite load in the spleen when compared with control mice. Cytokine analysis showed that the BALB/XID mice had lower amounts of IL-10 in their sera compared with control group. In addition, the transfer of B-1 cells from wild type mice into IL-10KO animals led to an increase in susceptibility to L. (L.) chagasi infection in the IL-10KO mice, suggesting that the IL-10 produced by these cells is important in experimental infection. Our results suggest that B-1 cells may play an important role in susceptibility to L. (L.) chagasi. (AU)

Processo FAPESP: 12/11837-6 - Avaliação da participação de linfócitos B-1 na leishmaniose experimental
Beneficiário:Patricia Xander Batista
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 10/19569-5 - Estudo do papel de linfócitos B-1 na infecção experimental por Leishmania (Leishmania) chagasi.
Beneficiário:Vanessa Xavier
Linha de fomento: Bolsas no Brasil - Iniciação Científica