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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

IFN-gamma Priming Effects on the Maintenance of Effector Memory CD4(+) T Cells and on Phagocyte Function: Evidences from Infectious Diseases

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Autor(es):
da Silva, Henrique Borges [1, 2] ; Fonseca, Raissa [1] ; Alvarez, Jose M. [1] ; D'Imperio Lima, Maria Regina [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55414 - USA
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: CLINICAL & DEVELOPMENTAL IMMUNOLOGY; 2015.
Citações Web of Science: 5
Resumo

Although it has been established that effector memory CD4(+) T cells play an important role in the protective immunity against chronic infections, little is known about the exact mechanisms responsible for their functioning and maintenance, as well as their effects on innate immune cells. Here we review recent data on the role of IFN-gamma priming as a mechanism affecting both innate immune cells and effector memory CD4(+) T cells. Suboptimal concentrations of IFN-gamma are seemingly crucial for the optimization of innate immune cell functions (including phagocytosis and destruction of reminiscent pathogens), as well as for the survival and functioning of effector memory CD4(+) T cells. Thus, IFN-gamma priming can thus be considered an important bridge between innate and adaptive immunity. (AU)

Processo FAPESP: 14/00810-5 - Priming por IFN-gama durante a fase crônica da malária experimental: estudo dos mecanismos moleculares e efetores envolvidos
Beneficiário:Henrique Borges da Silva
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 13/07140-2 - Papel dos inflamassomas na patogenia da tuberculose causada por isolados clínicos hipervirulentos de micobactérias
Beneficiário:Maria Regina D'Império Lima
Linha de fomento: Auxílio à Pesquisa - Regular