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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Cancer Cachexia and MicroRNAs

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Autor(es):
Camargo, Rodolfo Gonzalez [1, 2] ; Teixeira Ribeiro, Henrique Quintas [1] ; Geraldo, Murilo Vieira [2] ; Matos-Neto, Emidio [1] ; Neves, Rodrigo Xavier [1] ; Carnevali, Jr., Luiz Carlos [1] ; Donatto, Felipe Fedrizzi [1] ; Alcantara, Paulo S. M. [3] ; Ottoch, Jose P. [3] ; Seelaender, Marilia [1, 2]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, NAPmiR miRNA Res Grp, BR-05508000 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Dept Clin Surg, BR-05508000 Sao Paulo, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo de Revisão
Fonte: Mediators of Inflammation; 2015.
Citações Web of Science: 8
Resumo

Cancer cachexia is a paraneoplastic syndrome compromising quality of life and survival, mainly characterized by involuntary weight loss, fatigue, and systemic inflammation. The syndrome is described as a result of tumor-host interactions characterized by an inflammatory response by the host to the presence of the tumor. Indeed, systemic inflammation is considered a pivotal feature in cachexia progression and maintenance. Cytokines are intimately related to chronic systemic inflammation and the mechanisms underlying the release of these factors are not totally elucidated, the etiology of cachexia being still not fully understood. Therefore, the understanding of cachexia-related mechanisms, as well as the establishment of markers for the syndrome, is very relevant. MicroRNAs (miRNAs) are a class of noncoding RNAs interfering with gene regulation. Different miRNA expression profiles are associated with different diseases and inflammatory processes. miRNAs modulate adipose and skeletal muscle tissue metabolism in cancer cachexia and also tumor and tissue derived inflammation. Therefore, we propose a possible role for miRNAs in the modulation of the host inflammatory response during cachexia. Moreover, the establishment of a robust body of evidence in regard to miRNAs and the mechanisms underlying cachexia is mandatory, and shall contribute to the improvement of its diagnosis and treatment. (AU)

Processo FAPESP: 12/50079-0 - Inflamação sistêmica em pacientes com caquexia associada ao câncer: mecanismos e estratégias terapêuticas, uma abordagem em medicina translacional
Beneficiário:Marilia Cerqueira Leite Seelaender
Linha de fomento: Auxílio à Pesquisa - Temático