Cancer as a Proinflammatory Environment: Metastasis and Cachexia

Autor(es)

Pinto, Nelson Inacio ^[1] ; Carnier, June ^[1] ; Oyama, Lila M. ^[1] ; Otoch, Jose Pinhata ^[2] ; Alcantara, Paulo Sergio ^[2] ; Tokeshi, Flavio ^[2] ; Nascimento, Claudia M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Fisiol, BR-04023062 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Clin Cirug, Univ Hosp, BR-05508000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Mediators of Inflammation; 2015.
• Citações Web of Science: 17

Resumo

The development of the syndrome of cancer cachexia and that of metastasis are related with a poor prognostic for cancer patients. They are considered multifactorial processes associated with a proinflammatory environment, to which tumour microenvironment and other tissues from the tumour bearing individuals contribute. The aim of the present review is to address the role of ghrelin, myostatin, leptin, HIF, IL-6, TNF-alpha, and ANGPTL-4 in the regulation of energy balance, tumour development, and tumoural cell invasion. Hypoxia induced factor plays a prominent role in tumour macro-and microenvironment, by modulating the release of proinflammatory cytokines. (AU)

• Processo FAPESP: 12/50079-0 - Inflamação sistêmica em pacientes com caquexia associada ao câncer: mecanismos e estratégias terapêuticas, uma abordagem em medicina translacional
• Beneficiário: Marilia Cerqueira Leite Seelaender
• Modalidade de apoio: Auxílio à Pesquisa - Temático