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(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

NGAL urinária em pacientes sem e com lesão renal aguda em unidade de terapia intensiva

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Autor(es):
Mirian Watanabe ; Gabriela Fulan e Silva ; Cassiane Dezoti da Fonseca ; Maria de Fatima Fernandes Vattimo
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: Revista Brasileira de Terapia Intensiva; v. 26, n. 4, p. 347-354, Dez. 2014.
Resumo

Objective: To assess the diagnostic and prognostic efficacy of urine neutrophil gelatinase-associated lipocalin in patients admitted to an intensive care unit. Methods: Longitudinal, prospective cohort study conducted in a cardiology intensive care unit. The participants were divided into groups with and without acute kidney injury and were followed from admission to the intensive care unit until hospital discharge or death. Serum creatinine, urine output and urine neutrophil gelatinase-associated lipocalin were measured 24 and 48 hours after admission. Results: A total of 83 patients admitted to the intensive care unit for clinical reasons were assessed, most being male (57.8%). The participants were divided into groups without acute kidney injury (N=18), with acute kidney injury (N=28) and with severe acute kidney injury (N=37). Chronic diseases, mechanical ventilation and renal replacement therapy were more common in the groups with acute kidney injury and severe acute kidney injury, and those groups exhibited longer intensive care unit stay and hospital stay and higher mortality. Serum creatinine did not change significantly in the group with acute kidney injury within the first 24 hours of admission to the intensive care unit, although, urine neutrophil gelatinase-associated lipocalin was high in the groups with acute kidney injury and severe acute kidney injury (p<0.001). Increased urine neutrophil gelatinase-associated lipocalin was associated with death. Conclusion: An increase in urine neutrophil gelatinase-associated lipocalin precedes variations in serum creatinine in patients with acute kidney injury and may be associated with death. (AU)

Processo FAPESP: 11/24028-6 - O efeito do inibidor da fosfodiestarese-5 na lesão renal aguda isquêmica em ratos
Beneficiário:Mirian Watanabe
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 10/07656-0 - Neutrophil gelatinase associated lipocalin (NGAL) e evolução da lesão renal aguda em pacientes de terapia intensiva
Beneficiário:Maria de Fatima Fernandes Vattimo
Linha de fomento: Auxílio à Pesquisa - Regular