| Texto completo | |
| Autor(es): |
Martins, Douglas de J.
[1]
;
Hanif-Ur-Rehman
[1]
;
Alves Rico, Samara R.
[1]
;
Costa, Iguatina de M.
[1]
;
Pio Santos, Andrea C.
[1]
;
Szszudlowski, Rachel G.
[1]
;
Silva, Denise de Oliveira
[1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | RSC ADVANCES; v. 5, n. 109, p. 90184-90192, 2015. |
| Citações Web of Science: | 3 |
| Resumo | |
This manuscript reports a novel hybrid system containing a copper-drug entrapped into the chitosan biopolymer. Chitosan beads (CTb) were prepared and investigated for interaction with a copper metallodrug (CuNpx) of the naproxen (HNpx) non-steroidal anti-inflammatory drug. The loading capacity of CTb for CuNpx suggests a sponge-like behavior for copper-drug entrapping at a CuNpx concentration range from 10(-4) to 10(-2) mol L-1. A novel CTb/CuNpx hybrid material formed by the copper-drug loaded into chitosan beads was prepared and characterized by elemental analysis, scanning electron microscopy, electronic absorption spectroscopy, FTIR spectroscopy, X-ray diffractometry and thermal analysis. The CTb/CuNpx hybrid material was coated with Acrycoat S100, and its behavior in gastric/intestinal pH simulated solutions was investigated to verify potential releasing properties. The coated beads showed a capacity to release naproxen in a sustained release manner for at least 24 h. (AU) | |
| Processo FAPESP: | 05/60596-8 - Espécies complexas com potencial aplicação em bioinorgânica, catálise, farmacologia e química ambiental: concepção, preparação, caracterização e reatividade |
| Beneficiário: | Ana Maria da Costa Ferreira |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 11/06592-1 - Metalofármacos anti-inflamatórios e antitumorais: reatividade, propriedades e interações com matrizes hospedeiras biocompatíveis |
| Beneficiário: | Denise de Oliveira Silva |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |