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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Melanocytes are more responsive to IFN-gamma and produce higher amounts of kynurenine than melanoma cells

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Autor(es):
Clara, Renan Orsati [1] ; Assmann, Nadine [2] ; Ramos Moreno, Ana Carolina [1] ; Coimbra, Janine Baptista [1] ; Nurenberger, Nadine [2] ; Dettmer-Wilde, Katja [2] ; Oefner, Peter Josef [2] ; Campa, Ana [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Clin Chem, Fac Pharmaceut Sci, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Regensburg, Inst Funct Genom, D-93051 Regensburg - Germany
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Biological Chemistry; v. 397, n. 1, p. 85-90, JAN 2016.
Citações Web of Science: 1
Resumo

A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-gamma (IFN-gamma) and related to poor prognosis in melanomas. Besides its role in cancer, IFN-gamma plays a key role in the control of pigmentation homeostasis. Here we measured KP metabolites in human melanoma lines and skin melanocytes and fibroblasts in response to IFN-gamma. In general, IFN-gamma affected KP in skin cells more than in melanoma cells, supporting IFN-gamma roles in skin physiology and that of stromal cells in modulating the tumor microenvironment. (AU)

Processo FAPESP: 10/18477-0 - Metabolismo de triptofano em melanomas: o que dizem as células do microambiente?
Beneficiário:Renan Orsati Clara
Linha de fomento: Bolsas no Brasil - Doutorado