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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Tityus serrulatus venom - A lethal cocktail

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Autor(es):
Pucca, Manuela Berto [1] ; Cemi, Felipe Augusto [1] ; Pinheiro Junior, Ernesto Lopes [1] ; Figueiredo Bordon, Karla de Castro [1] ; Amorim, Femanda Gobbi [1] ; Cordeiro, Francielle Almeida [1] ; Longhim, Heloisa Tavoni [1] ; Cremonez, Caroline Marroni [1] ; Oliveira, Guilherme Honda [1] ; Arantes, Eliane Candiani [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Chem & Phys, BR-14040903 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo de Revisão
Fonte: Toxicon; v. 108, p. 272-284, DEC 15 2015.
Citações Web of Science: 28
Resumo

Tityus serrulatus (Ts) is the main scorpion species of medical importance in Brazil. Ts venom is composed of several compounds such as mucus, inorganic salts, lipids, amines, nucleotides, enzymes, kallikrein inhibitor, natriuretic peptide, proteins with high molecular mass, peptides, free amino acids and neurotoxins. Neurotoxins are considered the most responsible for the envenoming syndrome due to their pharmacological action on ion channels such as voltage-gated sodium (Nay) and potassium OM channels. The major goal of this review is to present important advances in Ts envenoming research, correlating both the crude Ts venom and isolated toxins with alterations observed in all human systems. The most remarkable event lies in the Ts induced massive releasing of neurotransmitters influencing, directly or indirectly, the entire body. Ts venom proved to extremely affect nervous and muscular systems, to modulate the immune system, to induce cardiac disorders, to cause pulmonary edema, to decrease urinary flow and to alter endocrine, exocrine, reproductive, integumentary, skeletal and digestive functions. Therefore, Is venom possesses toxins affecting all anatomic systems, making it a lethal cocktail. However, its low lethality may be due to the low venom mass injected, to the different venom compositions, the body characteristics and health conditions of the victim and the local of Ts sting. Furthermore, we also described the different treatments employed during envenoming cases. In particular, throughout the review, an effort will be made to provide information from an extensive documented studies concerning Is venom in vitro, in animals and in humans (a total of 151 references). (C) 2015 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 14/07824-1 - Caracterização estrutural e funcional de toxinas de interesse biotecnológico presentes na fração i da peçonha de Tityus serrulatus
Beneficiário:Heloisa Tavoni Longhim Peccin
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 11/12317-3 - Clonagem e expressão heteróloga da hialuronidase e/ou novas toxinas obtidas a partir do transcriptoma da glândula da peçonha de Tityus serrulatus
Beneficiário:Fernanda Gobbi Amorim
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 12/12954-6 - Estudo das toxinas Ts6 e Ts15 do escorpião Tityus serrulatus como potenciais drogas terapêuticas para o tratamento de doenças autoimunes
Beneficiário:Manuela Berto Pucca
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 12/13590-8 - Isolamento, caracterização molecular e funcional de uma nova toxina presente na peçonha do escorpião Tityus serrulatus
Beneficiário:Felipe Augusto Cerni
Linha de fomento: Bolsas no Brasil - Doutorado