Tityus serrulatus venom - A lethal cocktail

Autor(es)

Pucca, Manuela Berto ^[1] ; Cemi, Felipe Augusto ^[1] ; Pinheiro Junior, Ernesto Lopes ^[1] ; Figueiredo Bordon, Karla de Castro ^[1] ; Amorim, Femanda Gobbi ^[1] ; Cordeiro, Francielle Almeida ^[1] ; Longhim, Heloisa Tavoni ^[1] ; Cremonez, Caroline Marroni ^[1] ; Oliveira, Guilherme Honda ^[1] ; Arantes, Eliane Candiani ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Chem & Phys, BR-14040903 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Toxicon; v. 108, p. 272-284, DEC 15 2015.
• Citações Web of Science: 27

Resumo

Tityus serrulatus (Ts) is the main scorpion species of medical importance in Brazil. Ts venom is composed of several compounds such as mucus, inorganic salts, lipids, amines, nucleotides, enzymes, kallikrein inhibitor, natriuretic peptide, proteins with high molecular mass, peptides, free amino acids and neurotoxins. Neurotoxins are considered the most responsible for the envenoming syndrome due to their pharmacological action on ion channels such as voltage-gated sodium (Nay) and potassium OM channels. The major goal of this review is to present important advances in Ts envenoming research, correlating both the crude Ts venom and isolated toxins with alterations observed in all human systems. The most remarkable event lies in the Ts induced massive releasing of neurotransmitters influencing, directly or indirectly, the entire body. Ts venom proved to extremely affect nervous and muscular systems, to modulate the immune system, to induce cardiac disorders, to cause pulmonary edema, to decrease urinary flow and to alter endocrine, exocrine, reproductive, integumentary, skeletal and digestive functions. Therefore, Is venom possesses toxins affecting all anatomic systems, making it a lethal cocktail. However, its low lethality may be due to the low venom mass injected, to the different venom compositions, the body characteristics and health conditions of the victim and the local of Ts sting. Furthermore, we also described the different treatments employed during envenoming cases. In particular, throughout the review, an effort will be made to provide information from an extensive documented studies concerning Is venom in vitro, in animals and in humans (a total of 151 references). (C) 2015 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 12/12954-6 - Estudo das toxinas Ts6 e Ts15 do escorpião Tityus serrulatus como potenciais drogas terapêuticas para o tratamento de doenças autoimunes
• Beneficiário: Manuela Berto Pucca
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 11/12317-3 - Clonagem e expressão heteróloga da hialuronidase e/ou novas toxinas obtidas a partir do transcriptoma da glândula da peçonha de Tityus serrulatus
• Beneficiário: Fernanda Gobbi Amorim
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/07824-1 - Caracterização estrutural e funcional de toxinas de interesse biotecnológico presentes na fração I da peçonha de Tityus serrulatus
• Beneficiário: Heloisa Tavoni Longhim Peccin
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 12/13590-8 - Isolamento, caracterização molecular e funcional de uma nova toxina presente na peçonha do escorpião Tityus serrulatus.
• Beneficiário: Felipe Augusto Cerni
• Modalidade de apoio: Bolsas no Brasil - Doutorado