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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Shared Genetic Factors of Anxiety and Depression Symptoms in a Brazilian Family-Based Cohort, the Baependi Heart Study

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Autor(es):
Taporoski, Tamara P. [1, 2] ; Negrao, Andre B. [1, 2] ; Horimoto, Andrea R. V. R. [2] ; Duarte, Nubia E. [2] ; Alvim, Rafael O. [3, 2] ; de Oliveira, Camila M. [3, 2] ; Krieger, Jose E. [2] ; von Schantz, Malcolm [2, 4] ; Vallada, Homero [1] ; Pereira, Alexandre C. [2]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med, Dept & Inst Psychiat LIM 23, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Sch Med, Inst Heart, Lab Genet & Mol Cardiol, Sao Paulo, SP - Brazil
[3] Univ Fed Juiz de Fora, Dept Physiol, Juiz De Fora, MG - Brazil
[4] Univ Surrey, Fac Hlth & Med Sci, Dept Biochem & Physiol, Guildford GU2 5XH, Surrey - England
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: PLoS One; v. 10, n. 12 DEC 9 2015.
Citações Web of Science: 6
Resumo

To investigate the phenotypic and genetic overlap between anxiety and depression symptoms in an admixed population from extended family pedigrees. Participants (n = 1,375) were recruited from a cohort of 93 families (mean age +/- SD 42 +/- 16.3, 57% female) in the rural town of Baependi, Brazil. The Hospital Anxiety and Depression Scale (HADS) was used to assess depression and anxiety symptoms. Heritability estimates were obtained by an adjusted variance component model. Bivariate analyses were performed to obtain the partition of the covariance of anxiety and depression into genetic and environmental components, and to calculate the genetic contribution modulating both sets of symptoms. Anxiety and depression scores were 7.49 +/- 4.01 and 5.70 +/- 3.82, respectively. Mean scores were affected by age and were significantly higher in women. Heritability for depression and anxiety, corrected for age and sex, were 0.30 and 0.32, respectively. Significant genetic correlations (p(g) = 0.81) were found between anxiety and depression scores; thus, nearly 66% of the total genetic variance in one set of symptoms was shared with the other set. Our results provided strong evidence for a genetic overlap between anxiety and depression symptoms, which has relevance for our understanding of the biological basis of these constructs and could be exploited in genome-wide association studies. (AU)

Processo FAPESP: 13/17368-0 - Genômica cardiovascular: mechanismos & novas terapias - CVGen mech2ther
Beneficiário:José Eduardo Krieger
Linha de fomento: Auxílio à Pesquisa - Temático