Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Water deprivation-partial rehydration induces sensitization of sodium appetite and alteration of hypothalamic transcripts

Texto completo
Autor(es):
Pereira-Derderian, Daniela T. B. [1] ; Vendramini, Regina C. [2] ; Menani, Jose V. [1] ; Chiavegatto, Silvana [3] ; De Luca, Jr., Laurival A. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Sao Paulo - Brazil
[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, BR-14801903 Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY; v. 310, n. 1, p. R15-R23, JAN 1 2016.
Citações Web of Science: 3
Resumo

Sodium intake occurs either as a spontaneous or induced behavior, which is enhanced, i.e., sensitized, by repeated episodes of water deprivation followed by subsequent partial rehydration (WD-PR). In the present work, we examined whether repeated WD-PR alters hypothalamic transcripts related to the brain renin-angiotensin system (RAS) and apelin system in male normotensive Holtzman rats (HTZ). We also examined whether the sodium intake of a strain with genetically inherited high expression of the brain RAS, the spontaneously hypertensive rat (SHR), responds differently than HTZ to repeated WD-PR. We found that repeated WD-PR, besides enhancing spontaneous and induced 0.3 M NaCl intake, increased the hypothalamic expression of angiotensinogen, aminopeptidase N, and apelin receptor transcripts (43%, 60%, and 159%, respectively) in HTZ at the end of the third WD-PR. Repeated WD-PR did not change the daily spontaneous 0.3 M NaCl intake and barely changed the need-induced 0.3 M NaCl intake of SHR. The same treatment consistently enhanced spontaneous daily 0.3 M NaCl intake in the normotensive Wistar-Kyoto rats. The results show that repeated WD-PR produces alterations in hypothalamic transcripts and also sensitizes sodium appetite in HTZ. They suggest an association between the components of hypothalamic RAS and the apelin system, with neural and behavioral plasticity produced by repeated episodes of WD-PR in a normotensive strain. The results also indicate that the inherited hyperactive brain RAS is not a guarantee for sensitization of sodium intake in the male adult SHR exposed to repeated WD-PR. (AU)

Processo FAPESP: 11/50770-1 - Mecanismos neurais de regulação do equilíbrio hidroeletrolítico e controle cardiorrespiratório
Beneficiário:José Vanderlei Menani
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 09/01333-8 - Administração prolongada do ácido 13 cis-retinóico (isotretinoína) em camundongos machos adolescentes: comportamentos emocionais e níveis de RNA mensageiro de vários receptores de serotonina centrais
Beneficiário:Silvana Chiavegatto
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 03/12583-9 - Alteracoes de longo prazo no apetite ao sodio: aspectos neuroendocrinos e genomicos.
Beneficiário:Laurival Antonio de Luca Junior
Linha de fomento: Auxílio à Pesquisa - Regular