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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Frequencies and Associations of Narcolepsy-Related Symptoms: A Cross-Sectional Study

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Autor(es):
Kim, Lenise Jihe [1] ; Coelho, Fernando Morgadinho [1, 2] ; Hirotsu, Camila [1] ; Araujo, Paula [1] ; Bittencourt, Lia [1] ; Tufik, Sergio [1] ; Andersen, Monica Levy [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Neurol & Neurocirurgia, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF CLINICAL SLEEP MEDICINE; v. 11, n. 12, p. 1377-1384, 2015.
Citações Web of Science: 6
Resumo

Objectives: Narcolepsy is a disabling disease with a delayed diagnosis. At least 3 years before the disorder identification, several comorbidities can be observed in patients with narcolepsy. The early recognition of narcolepsy symptoms may improve long-term prognosis of the patients. Thus, we aimed to investigate the prevalence of the symptoms associated with narcolepsy and its social and psychological association in a sample of Sao Paulo city inhabitants. Methods: We performed a cross-sectional evaluation with 1,008 individuals from the Sao Paulo Epidemiologic Sleep Study (EPISONO). Excessive daytime sleepiness (EDS) was assessed by the Epworth Sleepiness Scale. Volunteers were also asked about the occurrence of cataplectic-like, hypnagogic or hypnopompic hallucinations, and sleep paralysis symptoms. The participants underwent a full-night polysomnography and completed questionnaires about psychological, demographic, and quality of life parameters. Results: We observed a prevalence of 39.2% of EDS, 15.0% of cataplectic-like symptom, 9.2% of hypnagogic or hypnopompic hallucinations, and 14.9% of sleep paralysis in Sao Paulo city inhabitants. A frequency of 6.9% waswai observed when EDS and cataplectic-like symptoms were grouped. The other associations were EDS + hallucinations (4.7%) and EDS + sleep paralysis (7.5%). Symptomatic participants were predominantly women and younger compared with patients without any narcolepsy symptom (n = 451). Narcolepsy symptomatology was also associated with a poor quality of life and symptoms of depression, anxiety, and fatigue. Conclusions: Narcolepsy-related symptoms are associated with poor quality of life and worse psychological parameters. (AU)

Processo FAPESP: 13/14420-1 - Efeitos da restrição de sono em modelo animal de lesão cerebral isquêmica
Beneficiário:Lenise Jihe Kim
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 14/15259-2 - Epidemiologia do sono na Cidade de São Paulo: seguimento dos voluntários do estudo de base EPISONO
Beneficiário:Camila Hirotsu
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 14/10255-9 - Ativação inflamatória induzida pela privação de sono: possível relação entre redução do tempo de sono e prejuízos no metabolismo lipídico
Beneficiário:Paula Cristina Alves Araújo
Linha de fomento: Bolsas no Brasil - Pós-Doutorado