Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Parthenogenesis and Human Assisted Reproduction

Texto completo
Autor(es):
Bos-Mikich, Adriana [1] ; Bressan, Fabiana F. [2] ; Ruggeri, Rafael R. [1] ; Watanabe, Yeda [3] ; Meirelles, Flavio V. [2]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Fed Rio Grande do Sul, ICBS, Dept Morphol Sci, BR-90050170 Porto Alegre, RS - Brazil
[2] Univ Sao Paulo, Fac Anim Sci & Food Engn FZEA, Dept Vet Med, BR-13635000 Pirassununga, SP - Brazil
[3] WTA Fertilizacao In Vitro Ltda, BR-14140000 Cravinhos, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo de Revisão
Fonte: STEM CELLS INTERNATIONAL; 2016.
Citações Web of Science: 7
Resumo

Parthenogenetic activation of human oocytes obtained from infertility treatments has gained new interest in recent years as an alternative approach to create embryos with no reproductive purpose for research in areas such as assisted reproduction technologies itself, somatic cell, and nuclear transfer experiments and for derivation of clinical grade pluripotent embryonic stem cells for regenerative medicine. Different activating methods have been tested on human and nonhuman oocytes, with varying degrees of success in terms of parthenote generation rates, embryo development stem cell derivation rates. Success in achieving a standardized artificial activation methodology for human oocytes and the subsequent potential therapeutic gain obtained from these embryos depends mainly on the availability of gametes donated from infertility treatments. This review will focus on the creation of parthenotes from clinically unusable oocytes for derivation and establishment of human parthenogenetic stem cell lines and their potential applications in regenerative medicine. (AU)

Processo FAPESP: 13/08135-2 - CTC - Centro de Terapia Celular
Beneficiário:Dimas Tadeu Covas
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs