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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Response to immunization in children born to renal transplant recipients using immunosuppressive drugs during gestation

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Autor(es):
Saraiva Dinelli, Maria Isabel [1] ; Ono, Erika [1] ; Viana, Patricia Oliveira [1] ; Spina, Fernanda Garcia [1] ; Weckx, Lily Yin [1] ; Nunes dos Santos, Amelia Miyashiro [1] ; de Moraes-Pinto, Maria Isabel [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Pediat, Div Pediat Infect Dis, Rua Pedro Toledo, 781-9 Andar Sao Paulo, BR-04039032 Sao Paulo, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Vaccine; v. 34, n. 4, p. 404-407, JAN 20 2016.
Citações Web of Science: 3
Resumo

The use of immunosuppressive drugs can impair vaccination responses. When used during pregnancy, they may interfere with the development of the fetus's immune system. However, little is known regarding their influence on infant's response to vaccinations. Twenty-seven children born to renal transplant mothers (Tx) taking immunosuppressive drugs and 31 healthy children had the humoral immune response and reactogenicity to tetanus, Haemophilus influenzae type b (Hib) and 7 pneumococcal serotypes evaluated. The evolution of BCG vaccine scar was also registered. Antibodies were measured by ELISA. Lymphocyte immunophenotyping was performed on cord blood and at 7-8 months of age. Among Tx neonates, 82.4% had low B lymphocyte numbers at birth, and 29.4% had also low numbers of other lymphocyte subpopulations. Nevertheless, all children developed protective antibodies with similar antibody concentrations to the control group. Vaccine reactogenicity was similar in both groups and BCG healing was uneventful. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 08/11670-9 - Crianças nascidas de mulheres submetidas a transplante renal: avaliação imunológica, passagem transplacentária de anticorpos e resposta a vacinação
Beneficiário:Maria Isabel de Moraes Pinto
Linha de fomento: Auxílio à Pesquisa - Regular