Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Coronary artery calcification score is an independent predictor of the no-reflow phenomenon after reperfusion therapy in acute myocardial infarction

Texto completo
Autor(es):
Mostrar menos -
Modolo, Rodrigo [1] ; Figueiredo, Valeria N. [1] ; Moura, Filipe A. [1] ; Almeida, Breno [1] ; Quinaglia e Silva, Jose C. [2] ; Nadruz, Jr., Wilson [1] ; Lemos, Pedro A. [3] ; Coelho, Otavio R. [1] ; Blaha, Michael J. [4] ; Sposito, Andrei C. [1] ; Grp, Brasilia Heart Study
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Campinas Unicamp, Fac Med Sci, Div Cardiol, Dept Internal Med, Campinas, SP - Brazil
[2] Escola Super Ciencias Saude, Brasilia, DF - Brazil
[3] Univ Sao Paulo, Dept Intervent Cardiol Heart Inst INCOR, Sao Paulo - Brazil
[4] Johns Hopkins Ciccarone Ctr Prevent Heart Dis, Baltimore, MD - USA
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Coronary Artery Disease; v. 26, n. 7, p. 562-566, NOV 2015.
Citações Web of Science: 4
Resumo

Aim/Background Abundant evidence shows that coronary artery calcification (CAC) is a strong marker of structural and functional changes within the artery wall. Thus far, the implications of CAC in patients with acute coronary syndromes remain unclear. We aimed to investigate whether the CAC score is associated with impaired reperfusion during the acute phase of ST-elevation myocardial infarction (STEMI). Methods We enrolled 60 consecutive STEMI patients to undergo cardiac computed tomography for assessment of the CAC score within 1 week after STEMI. Coronary thrombus burden, coronary blood flow (TIMI flow), and myocardial blush grade (MBG) were evaluated systematically. Patients with maximal TIMI flow and MBG were grouped as optimal reperfusion (n = 27) and their counterparts as no-reflow (NR, n = 33). Results There were no differences in the clinical characteristics between groups. Patients in the NR group had higher heart rate, coronary angiographic severity, and CAC score. CAC score greater than 100 was associated independently with the presence of NR (odds ratio 4.4, 95% confidence interval 1.17-16.3). The CAC score of nonculprit coronary arteries was higher in NR individuals than in their counterparts (P = 0.04). In addition, the CAC score of the isnfarct-related artery correlated negatively with the TIMI-flow rate (r = -0.54, P < 0.001) and with the MBG (r = -0.32, P = 0.04). Conclusion The CAC score is associated with the presence of the NR phenomenon in STEMI patients. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved. (AU)

Processo FAPESP: 12/18044-1 - Efeito do tratamento com niacina sobre o metabolismo do HDL e a função endotelial em pacientes com HDL baixo com ou sem Hipertrigliceridemia.
Beneficiário:Valéria Nasser Figueiredo
Linha de fomento: Bolsas no Brasil - Pós-Doutorado