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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Estrogenic activities of diuron metabolites in female Nile tilapia (Oreochromis niloticus)

Texto completo
Autor(es):
Boscolo Pereira, Thiago Scremin [1] ; Pereira Boscolo, Camila Nomura [1] ; Felicio, Andreia Arantes [2] ; Batlouni, Sergio Ricardo [3] ; Schlenk, Daniel [4] ; de Almeida, Eduardo Alves [2]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista IBILCE UNESP, Dept Zool & Bot, Rua Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[2] Univ Estadual Paulista IBILCE UNESP, Dept Chem & Environm Sci, Rua Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[3] Univ Estadual Paulista CAUNESP, Aquaculture Ctr, Via Acesso Prof Paulo Donato Castelane S-N, BR-14884900 Jaboticabal, SP - Brazil
[4] Univ Calif Riverside, Dept Environm Sci, 3401 Watkins Dr, Riverside, CA 92521 - USA
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Chemosphere; v. 146, p. 497-502, MAR 2016.
Citações Web of Science: 11
Resumo

Some endocrine disrupting chemicals (EDCs) can alter the estrogenic activities of the organism by directly interacting with estrogen receptors (ER) or indirectly through the hypothalamus-pituitary gonadal axis. Recent studies in male Nile tilapia (Oreochromis niloticus) indicated that diuron may have anti-androgenic activity augmented by biotransformation. In this study, the effects of diuron and three of its metabolites were evaluated in female tilapia. Sexually mature female fish were exposed for 25 days to diuron, as well as to its metabolites 3,4-dichloroaniline (DCA), 3,4-dichlorophenylurea (DCPU) and 3,4-dichlorophenyl-N-methylurea (DCPMU), at concentrations of 100 ng/L. Diuron metabolites caused increases in E-2 plasma levels, gonadosomatic indices and in the percentage of final vitellogenic oocytes. Moreover, diuron and its metabolites caused a decrease in germinative cells. Significant differences in plasma concentrations of the estrogen precursor and gonadal regulator17 alpha-hydroxyprogesterone (17 alpha-OHP) were not observed. These results show that diuron metabolites had estrogenic effects potentially mediated through enhanced estradiol biosynthesis and accelerated the ovarian development of O. niloticus females. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 11/52061-8 - Efeitos bioquímicos e estrogênicos do Diuron e seus metabólitos, isoladamente ou em combinação com alquilfenois em Tilápias do Nilo (Oreochromis niloticus)
Beneficiário:Eduardo Alves de Almeida
Linha de fomento: Auxílio à Pesquisa - Programa BIOEN - Regular