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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Brain perfusion impairment in neurologically asymptomatic adult patients with sickle-cell disease shown by voxel-based analysis of SPECT images

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Autor(es):
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Deus-Silva, Leonardo [1] ; Bonilha, Leonardo [2] ; Damasceno, Benito P. [1] ; Costa, Andre L. F. [1, 3] ; Yasuda, Clarissa L. [1] ; Costa, Fernando F. [4] ; Santos, Allan O. [5] ; Etchebehere, Elba C. S. C. [5] ; Oquendo-Nogueira, Regis [5] ; Fockink, Renata [5] ; de Freitas, Claudio Froes [3] ; Camargo, Edwaldo E. [5] ; Li, Li M. [1] ; Cendes, Fernando [1] ; Saad, Sara T. [4]
Número total de Autores: 15
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Dept Neurol, Campinas, SP - Brazil
[2] Med Univ S Carolina, Dept Neurosci, Div Neurol, Charleston, SC 29425 - USA
[3] City Univ Sao Paulo, Dept Orthodont, Sao Paulo - Brazil
[4] Univ Estadual Campinas, Hematol & Hemotherapy Ctr, Campinas, SP - Brazil
[5] Univ Estadual Campinas, Dept Radiol, Div Nucl Med, Campinas, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN NEUROLOGY; v. 4, 2013.
Citações Web of Science: 4
Resumo

Cerebrovascular lesions are frequently observed in patients with sickle-cell disease (SCD) and these structural lesions are preceded by insidious perfusion deficits. Our aim was to investigate the presence of brain perfusion deficits in neurologically asymptomatic SCD patients, especially affecting microvessels. For this study, 42 SCD patients {[}33 sickle-cell anemia (HbSS), 6 sickle hemoglobin C disease (HbSC), and 3 sickle beta-thalassemia disease (HbS beta)] with mean hematocrit of 25.1 (+/- 4.85; 15.6-38.5) underwent brain perfusion single photon emission computerized tomography (SPECT) using the tracer Tc-99m-ECD. Images from SCD patients were compared to images of a healthy control group (29 females and 20 males, mean age 31 +/- 8; range 25-49 years). Images underwent voxel-wise comparison of regional tracer uptake using paired t-test to estimate the probability of each voxel to have an increased or decreased tracer uptake. When compared to controls, SCD patients exhibited significantly reduced tracer uptake in basal ganglia and thalami, the anterior frontal region and the watershed region of the temporo-parietal-occipital transition (p < 0.05). Our study showed that neurologically asymptomatic adult SCD patients exhibit a pattern of reduced 99mTc-ECD tracer uptake demonstrated by SPECT. Early diagnosis of this cerebral vasculopathy has prognostic implications and can be determinant in considering therapeutic alternatives to avoid increasing brain lesion load and progressive disability. (AU)

Processo FAPESP: 00/04710-2 - Magnitude do dano neuronal e o seu valor prognóstico em pacientes com epilepsia do lobo temporal crônica refratária e recém-diagnosticada: um estudo com ressonância magnética quantitativa
Beneficiário:Li Li Min
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
Processo FAPESP: 03/11490-7 - Alterações cerebrovasculares de pacientes adultos com doenças falciformes: avaliação da neuroimagem com ressonância magnética, Doppler Transcraniano e SPECT cerebral
Beneficiário:Benito Pereira Damasceno
Linha de fomento: Auxílio à Pesquisa - Regular