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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Sleep, Hansen's disease and the immune system - A not so harmonic triad

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Autor(es):
Albuquerque, Rachel Gimenes [1] ; Okazaki, Keity Mey [1] ; Hirotsu, Camila [1] ; Tomimori, Jane [2] ; Tufik, Sergio [1] ; Andersen, Monica Levy [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Dermatol, BR-04038001 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Medical Hypotheses; v. 84, n. 5, p. 456-459, MAY 2015.
Citações Web of Science: 0
Resumo

Hansen's disease is one of the oldest skin diseases in the world characterized by a spectrum of clinical manifestations that are associated with stigmatization and poor quality of life. It is also considered a model disease for investigating the human immune system because of its association with immune reactions, which are thought to be a reflection of the host's immunological response, promoting intense cellular activity or humoral secretion. This relationship between the cellular and microbial components of skin and their regulation by local immune responses may be modulated by a currently neglected behavior: sleep. Recent studies have demonstrated that sleep deprivation may aggravate the progression of chronic dermatological diseases, which in turn can lead to a non-restorative sleep pattern. Indeed, sleep is essential for immune and skin integrity. Thus, we propose here a hypothesis linking Hansen's disease, sleep and immunity in a bidirectional relationship. Hansen's disease patients may demonstrate a worse sleep quality than the general population through the modulation of immunological environment; and sleep restriction, a hallmark of modern society, being a possible predictor of the disease progression. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 14/00923-4 - Impacto da restrição e privação de sono sobre o envelhecimento de pele em ratos
Beneficiário:Rachel Gimenes Rodrigues Albuquerque
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 12/21794-2 - A importância do sono e do sildenafil na progressão da insuficiência renal crônica: uma nova abordagem terapêutica
Beneficiário:Monica Levy Andersen
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 14/15259-2 - Epidemiologia do sono na Cidade de São Paulo: seguimento dos voluntários do estudo de base EPISONO
Beneficiário:Camila Hirotsu
Linha de fomento: Bolsas no Brasil - Pós-Doutorado