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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Biomonitoring of mutagenicity and cytotoxicity in patients undergoing fixed orthodontic therapy

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Autor(es):
Angelieri, Fernanda [1] ; Carlin, Viviane [2] ; Martins, Renato A. [3] ; Ribeiro, Daniel A. [3, 2]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Sao Paulo Methodist Univ, Dept Orthodont, Sao Bernardo Do Campo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Pathol, Paulista Med Sch, Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo, Dept Biociencias, BR-11060001 Santos, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS; v. 139, n. 4, 1 APR 2011.
Citações Web of Science: 14
Resumo

Introduction: The aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis, and karyorrhexis) in exfoliated buccal mucosa cells from adults after fixed orthodontic therapy. Material and Methods: A total of 23 healthy adults (10 men and 13 women) undergoing orthodontic therapy were included in this setting. Results: The results pointed out no significant statistically differences (P > 0.05) of micronucleated oral mucosa cells. In the same way, orthodontic therapy was not able to increase other nuclear alterations closely related to cytotoxicity such as karyorrhexis, pyknosis and karyolysis (P > 0.05). Conclusion: In summary, these data indicate that orthodontic therapy may not be a factor that induces chromosomal damage, nor it is able to promote cytotoxicity. Since DNA damage and cellular death are important events during carcinogenic processes, especially in early phases, this study represents a correct evaluation with respect to real health risks induced by orthodontic devices. (Am J Orthod Dentofacial Orthop 2011; 139:e399-e404) (AU)

Processo FAPESP: 07/00345-7 - Danos no DNA promovidos por íons metálicos provenientes de aparelhos ortodônticos fixos: análises in vitro e in vivo
Beneficiário:Daniel Araki Ribeiro
Linha de fomento: Auxílio à Pesquisa - Regular