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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Antimicrobial Activity of Oleanolic and Ursolic Acids: An Update

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Autor(es):
Jesus, Jessica A. [1, 2] ; Lago, Joao Henrique G. [1] ; Laurenti, Marcia D. [2] ; Yamamoto, Eduardo S. [2] ; Passero, Luiz Felipe D. [2]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Dept Patol, Lab Patol Molestias Infecciosas, BR-06780210 Sao Paulo, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: Evidence-based Complementary and Alternative Medicine; 2015.
Citações Web of Science: 19
Resumo

Triterpenoids are the most representative group of phytochemicals, as they comprise more than 20,000 recognized molecules. These compounds are biosynthesized in plants via squalene cyclization, a C-30 hydrocarbon that is considered to be the precursor of all steroids. Due to their low hydrophilicity, triterpenes were considered to be inactive for a long period of time; however, evidence regarding their wide range of pharmacological activities is emerging, and elegant studies have highlighted these activities. Several triterpenic skeletons have been described, including some that have presented with pentacyclic features, such as oleanolic and ursolic acids. These compounds have displayed incontestable biological activity, such as antibacterial, antiviral, and antiprotozoal effects, which were not included in a single review until now. Thus, the present review investigates the potential use of these triterpenes against human pathogens, including their mechanisms of action, via in vivo studies, and the future perspectives about the use of compounds for human or even animal health are also discussed. (AU)

Processo FAPESP: 13/10133-8 - Análise da ação terapêutica dos ácidos oleanólico e ursólico na leishmaniose visceral experimental
Beneficiário:Jéssica Adriana de Jesus
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 13/16297-2 - Análise dos potenciais anti-Leishmania e anti-Tripanossoma dos ácidos oleanólico e ursólico
Beneficiário:Luiz Felipe Domingues Passero
Linha de fomento: Auxílio à Pesquisa - Regular