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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Cocaine counteracts LPS-induced hypolocomotion and triggers locomotor sensitization expression

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Autor(es):
Tortorelli, Lucas Silva [1] ; Engelke, Douglas Senna [2, 3] ; Lunardi, Paula [1] ; Mello e Souza, Tadeu [1] ; Santos-Junior, Jair Guilherme [4] ; Goncalves, Carlos-Alberto [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Fed Rio Grande do Sul, Dept Biochem, Porto Alegre, RS - Brazil
[2] Univ Fed Sao Paulo, Neurobiol Lab, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Neurol & Neurosci Grad Program, Sao Paulo - Brazil
[4] Santa Casa Sch Med Sci, Dept Physiol Sci, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Behavioural Brain Research; v. 287, p. 226-229, JUL 1 2015.
Citações Web of Science: 5
Resumo

Neuroimmune signalling underlies addiction and comorbid depression. Clinical observations indicate that infections and chronic lesions are more frequent in drug users and elevated inflammatory states are evident in cocaine dependents. Therefore, lipopolysaccharide (LPS) and inflammatory cytokines represent an important tool for the investigation of sickness, depressive illness and addiction behaviour. A major component of addiction is the progressive and persistent increase in locomotor activity after repeated drug administration and even prolonged periods of abstinence. The aim of this study was to investigate the response of locomotor sensitization when a non-sensitizing dose of cocaine is paired with a systemic inflammatory stimulus. LPS and cocaine were administered intraperitonealy in young-adult male C57b1/6 mice during a 5-day acquisition phase. After a 48-h withdrawal period all groups were challenged with cocaine to evaluate locomotor expression. During the acquisition phase, the LPS-treated groups displayed characteristic hypolocomotion related to sickness behaviour. The low dose of cocaine did not increase the distance travelled, characterizing a non-sensitization dose. Groups that received both LPS and cocaine did not display hypolocomotion, indicating that cocaine might counteract hypolocomotion sickness behaviour. Moreover, during challenge, only these animals expressed locomotor sensitization. Our results indicate that LPS could facilitate the expression of locomotor sensitization in mice and that the immune system may modulate cocaine-induced sensitization. (C) 2015 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 09/16305-0 - Participação da PKM sobre as influências contextuais na sensibilização locomotora induzida pela anfetamina
Beneficiário:Douglas Senna Engelke
Linha de fomento: Bolsas no Brasil - Doutorado Direto