Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Cardiovascular responses elicited by continuous versus intermittent electrical stimulation of the aortic depressor nerve in conscious rats

Texto completo
Autor(es):
Brognara, Fernanda [1] ; Martins Dias, Daniel P. [1] ; Castania, Jaci A. [1] ; Fazan, Jr., Rubens [1] ; Lewis, Stephen J. [2] ; Salgado, Helio C. [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Physiol, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Case Western Reserve Univ, Sch Med, Dept Pharmacol, Dept Pediat, Div Pulmonol Allergy & Immunol, Cleveland, OH 44106 - USA
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Life Sciences; v. 148, p. 99-105, MAR 1 2016.
Citações Web of Science: 1
Resumo

Aims: Short-term (seconds or minutes) continuous electrical activation of the aortic depressor nerve (ADN) in conscious rats has been successfully used to investigate baroafferent function in experimental hypertension, heart failure, and peripheral inflammation. The aimof this studywas to characterize the hemodynamic responses elicited by longer periods (60 min) of continuous or intermittent electrical baroreflex activation. Main methods: Wistar rats were implanted with an electrode around the left ADN and a catheter into a femoral artery. The systolic, diastolic and mean arterial pressure and heart rate were recorded in subjects randomly assigned to continuous or intermittent electrical stimulation. The time-course of cardiovascular responses in conscious rats was examined during longer-term (60 min) continuous (n = 6) or intermittent (5 s ON/3 s OFF; n = 10) electrical stimulation (0.5 mA; 0.25 ms; 30 Hz) of the ADN. Key findings: The prompt (20 s) hypotensive response was greater under continuous stimulation, but no difference was detected in the bradycardic response. The hypotensive response was sustained only by continuous stimulation while no sustained bradycardia was observed in either protocol. Significance: These findings indicate that continuous stimulation of the ADN is more effective in reducing arterial pressure over a longer period (60 min) of stimulation. Nevertheless, both protocols-continuous or intermittent were unable to elicit a sustained bradycardia. (C) 2016 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 14/15386-4 - Modulação da resposta inflamatória ao LPS pela ativação elétrica do barorreflexo em ratos acordados
Beneficiário:Fernanda Brognara Penteado Dias
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 13/20549-7 - Avanços na regulação cardiocirculatória em condições fisiológica e fisiopatológica
Beneficiário:Helio Cesar Salgado
Linha de fomento: Auxílio à Pesquisa - Temático