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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Thyroid-Specific Genes Expression Uncovered Age-Related Differences in Pediatric Thyroid Carcinomas

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Autor(es):
Cunha Vieira Cordioli, Maria Isabel [1, 2] ; Moraes, Lais [1, 2] ; de Seixas Alves, Maria Teresa [3] ; Delcelo, Rosana [4] ; Monte, Osmar [5] ; Longui, Carlos Alberto [5] ; Cury, Adriano Namo [6] ; Cerutti, Janete Maria [1, 2]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Morphol & Genet, Div Genet, Genet Bases Thyroid Tumors Lab, Pedro de Toledo 669, 11 Andar, BR-04039032 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Med, Div Endocrinol, Pedro de Toledo 669, 11 Andar, BR-04039032 Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo, Dept Pathol, Pediat Sect, Rua Botucatu 740, BR-04023900 Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo, Dept Pathol, Thyroid Sect, Rua Botucatu 740, BR-04023900 Sao Paulo, SP - Brazil
[5] Irmandade Santa Casa Miserordia Sao Paulo, Mol Med Lab, Rua Dr Cesario Mota Jr 112, BR-01221020 Sao Paulo, SP - Brazil
[6] Irmandade Santa Casa Miserordia Sao Paulo, Div Endocrinol, Rua Dr Cesario Mota Jr 112, BR-01221020 Sao Paulo, SP - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: INTERNATIONAL JOURNAL OF ENDOCRINOLOGY; 2016.
Citações Web of Science: 8
Resumo

Despite a more advanced stage of disease at presentation, a better response to radioiodine (RAI) therapy and a reduced overall mortality have been reported in pediatric differentiated thyroid cancer (DTC) in comparison to adult DTC. Few studies suggested that the better response to RAI therapy in pediatric patients might be associated with an increased expression of NIS. However, a marked heterogeneity within the pediatric group has been recognized. Children (<10 years old) usually present a more aggressive disease than adolescents (>= 10-18 years old). By analyzing the expression of thyroid-specific genes in 38 sporadic pediatric tumors, we show that the expression of NIS, PDS, and TSHR was lower in children than adolescents (P < 0.05). A linear regression confirmed the association between NIS expression and age. Most significantly, NIS was expressed at similar levels in DTC from children and adults, whereas PDS and TSHR expression was even lower in DTC from children, compared to adolescents and adults. Our data suggest that biological behaviors of DTC in adolescents might differ from those in children and adults. Therefore, the premise that the expression of thyroid-specific genes is higher in tumors from pediatric patients than in adults is not entirely true and might be too oversimplified. (AU)

Processo FAPESP: 12/02902-9 - Investigação do papel dos microRNAs na regulação da expressão do gene C1orf24 em tumores da tiróide humana
Beneficiário:Janete Maria Cerutti
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/03867-5 - Análise da variação no número de cópias (CNV) de segmentos de DNA em pacientes de uma família com síndrome nem 2ª e mutação p.G533C no gene RET: identificação de regiões associadas à gênese e progressão do carcinoma medular da tiróide
Beneficiário:Janete Maria Cerutti
Linha de fomento: Auxílio à Pesquisa - Regular