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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Transfusion-Transmitted Dengue and Associated Clinical Symptoms During the 2012 Epidemic in Brazil

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Autor(es):
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Sabino, Ester C. [1] ; Loureiro, Paula [2] ; Lopes, Maria Esther [3] ; Capuani, Ligia [1] ; McClure, Christopher [4] ; Chowdhury, Dhuly [4] ; Di-Lorenzo-Oliveira, Claudia [5] ; Oliveira, Lea C. [1] ; Linnen, Jeffrey M. [6] ; Lee, Tzong-Hae [7] ; Goncalez, Thelma [7] ; Brambilla, Donald [4] ; Kleinman, Steve [7, 8] ; Busch, Michael P. [9, 7] ; Custer, Brian [9, 7] ; Epid, Int Component NHLBI Recipient
Número total de Autores: 16
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Trop Med, Dep Molestias Infecciosas & Parasitarias, Recife, PE - Brazil
[2] UPE Fundacao Hemope, Fac Ciencias Med, Recife, PE - Brazil
[3] Fundacao Hemorio, Rio De Janeiro - Brazil
[4] RTI Int, Rockville, MD - USA
[5] Univ Fed Sao Joao del Rey, Divinopolis - Brazil
[6] Hologic, San Diego, CA - USA
[7] Blood Syst Res Inst, 270 Masonic Ave, San Francisco, CA 94118 - USA
[8] Univ British Columbia, Vancouver, BC V5Z 1M9 - Canada
[9] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 - USA
Número total de Afiliações: 9
Tipo de documento: Artigo Científico
Fonte: Journal of Infectious Diseases; v. 213, n. 5, p. 694-702, MAR 1 2016.
Citações Web of Science: 41
Resumo

Background. A linked donor-recipient study was conducted during epidemics in 2 cities in Brazil to investigate transfusion-transmitted (TT) dengue virus (DENV) by DENV RNA-positive donations. Methods. During February-June 2012, samples were collected from donors and recipients and retrospectively tested for DENV RNA by transcription-mediated amplification. Recipient chart review, using a case (DENV positive)-control (DENV negative and not known to be exposed) design, was conducted to assess symptoms. Results. Of 39 134 recruited blood donors, DENV-4 viremia was confirmed in 0.51% of donations from subjects in Rio de Janeiro and 0.80% of subjects in Recife. Overall, 42 DENV RNA-positive units were transfused into 35 recipients. Of these, 16 RNA-positive units transfused into 16 susceptible recipients were identified as informative: 5 cases were considered probable TT cases, 1 possible TT case, and 10 nontransmissions. The TT rate was 37.5% (95% confidence interval {[}CI], 15.2%-64.6%), significantly higher than the viremia rate of 0.93% (95% CI, .11%-3.34%) in nonexposed recipients (P < .0001). Chart review did not find significant differences between cases and controls in symptoms or mortality. Conclusions. During a large epidemic of DENV-4 infection in Brazil, >0.5% of donations were RNA positive, and approximately one third of components resulted in TT. However, no significant clinical differences were evident between RNA-positive and RNA-negative recipients. (AU)

Processo FAPESP: 11/18955-1 - Prevalência de dengue em doadores e receptores de sangue brasileiros: índice de transmissão por transfusão e resultados clínicos de infecção por dengue em receptores
Beneficiário:Ester Cerdeira Sabino
Linha de fomento: Auxílio à Pesquisa - Regular