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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Antistaphylococcal Prenylated Acylphoroglucinol and Xanthones from Kielmeyera variabilis

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Autor(es):
Coqueiro, Aline [1, 2, 3] ; Choi, Young H. [3] ; Verpoorte, Robert [3] ; Gupta, Karthick B. S. S. [4] ; De Mier, Maria [5] ; Hamburger, Matthias [5] ; Young, Maria C. M. [6] ; Stapleton, Paul [2] ; Gibbons, Simon [2] ; Bolzani, Vanderlan da S. [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ, Inst Chem, Dept Organ Chem, Prof Francisco Degni 55, BR-14800900 Araraquara - Brazil
[2] UCL Sch Pharm, Res Dept Pharmaceut & Biol Chem, 29-39 Brunswick Sq, London WC1N 1AX - England
[3] Leiden Univ, Inst Biol, Nat Prod Lab, Sylviusweg 72, NL-2333 BE Leiden - Netherlands
[4] Leiden Univ, NMR Facil, Leiden Inst Chem, Einsteinweg 55, NL-2333 CC Leiden - Netherlands
[5] Univ Basel, Div Pharmaceut Biol, Klingelbergstr 50, CH-4056 Basel - Switzerland
[6] Inst Bot, Sect Plant Physiol & Biochem, BR-01061970 Sao Paulo - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: Journal of Natural Products; v. 79, n. 3, p. 470-476, MAR 2016.
Citações Web of Science: 10
Resumo

Bioactivity-guided fractionation of the EtOH extract of the branches of Kielmeyera variabilis led to the isolation of a new acylphoroglucinol (1), which was active against all the MRSA strains tested herein, with pronounced activity against strain EMRSA-16. Compound 1 displayed an MIC of 0.5 mg/L as compared with an MIC of 128 mg/L for the control antibiotic norfloxacin. The structure of the new compound was elucidated by 1D and 2D NMR spectroscopic analysis and mass spectrometry, and experimental and calculated ECD were used to determine the absolute configurations. The compounds beta-sitosterol (2), stigmasterol (3), ergost-5-en-3-ol (4), and osajaxanthone (5) also occurred in the n-hexane fraction. The EtOAc fraction contained nine known xanthones: 3,6-dihydroxy-1,4,8-trimethoxyxanthone (6), 3,5-dihydroxy-4-methoxyxanthone (7), 3,4-dihydroxy-6,8-dimethoxptanthone (8), 3,4-dihydroxy-2methoxyxanthone (9), 5-hydroxy-1,3-dimethoxyxanthone (10), 4-hydroxy-2,3-dimethoxyxanthone (11), kielcorin (12), 3hydroxy-2-methoxyxanthone (13), and 2-hydroxy-1-methoxyxanthone (14), which showed moderate to low activity against the tested MRSA strains. (AU)

Processo FAPESP: 03/02176-7 - Conservação e uso sustentável da diversidade do Cerrado e da Mata Atlântica: diversidade química e prospecção de medicamentos potenciais - fase II
Beneficiário:Vanderlan da Silva Bolzani
Linha de fomento: Auxílio à Pesquisa - Programa BIOTA - Temático
Processo FAPESP: 06/61187-7 - Fracionamento bioguiado para seleção de substâncias antioxidante, antimalárica e antibiótica potenciais nas espécies Kielmeyera variabilis (Clusiaceae) e Brosimum glaziovii (Moraceae)
Beneficiário:Aline Coqueiro
Linha de fomento: Bolsas no Brasil - Doutorado