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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Photosensitizing nanoparticles and the modulation of ROS generation

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Autor(es):
Tada, Dayane B. [1] ; Baptista, Mauricio S. [2]
Número total de Autores: 2
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Ciencia & Tecnol, Inst Ciencia & Tecnol, Rua Talim 330, BR-12231280 Sao Jose Dos Campos - Brazil
[2] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-01498 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: FRONTIERS IN CHEMISTRY; v. 3, MAY 27 2015.
Citações Web of Science: 21
Resumo

The association of PhotoSensitizer (PS) molecules with nanoparticles (NPs) forming photosensitizing NPs, has emerged as a therapeutic strategy to improve PS tumor targeting, to protect PS from deactivation reactions and to enhance both PS solubility and circulation time. Since association with NPs usually alters PS photophysical and photochemical properties, photosensitizing NPs are an important tool to modulate ROS generation. Depending on the design of the photosensitizing NP, i.e., type of PS, the NP material and the method applied for the construction of the photosensitizing NP, the deactivation routes of the excited state can be controlled, allowing the generation of either singlet oxygen or other reactive oxygen species (ROS). Controlling the type of generated ROS is desirable not only in biomedical applications, as in Photodynamic Therapy where the type of ROS affects therapeutic efficiency, but also in other technological relevant fields like energy conversion, where the electron and energy transfer processes are necessary to increase the efficiency of photoconversion cells. The current review highlights some of the recent developments in the design of Photosensitizing NPs aimed at modulating the primary photochemical events after light absorption. (AU)

Processo FAPESP: 13/07937-8 - Redoxoma
Beneficiário:Ohara Augusto
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 12/50680-5 - Fotossensibilização nas ciências da vida
Beneficiário:Mauricio da Silva Baptista
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 11/23895-8 - Caracterização e controle de mecanismos de internalização celular de nanopartículas
Beneficiário:Dayane Batista Tada
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores