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Functionalized Silica Nanoparticles As an Alternative Platform for Targeted Drug-Delivery of Water Insoluble Drugs

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Autor(es):
de Oliveira, Luciane Franca [1] ; Bouchmella, Karim [1] ; Goncalves, Kaliandra de Almeida [2] ; Bettini, Jefferson [3] ; Kobarg, Joerg [4, 5] ; Cardoso, Mateus Borba [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Lab Nacl Luz Sincrotron, Caixa Postal 6192, BR-13083970 Campinas, SP - Brazil
[2] Lab Nacl Biociencias LNBio, Caixa Postal 6192, BR-13083970 Campinas, SP - Brazil
[3] Lab Nacl Nanotecnol LNNano, Caixa Postal 6192, BR-13083970 Campinas, SP - Brazil
[4] Univ Estadual Campinas, UNICAMP, Fac Ciencias Farmaceut, Caixa Postal 6154, BR-13083970 Campinas, SP - Brazil
[5] Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Bioquim & Biol Tecidual, Caixa Postal 6154, BR-13083970 Campinas, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Langmuir; v. 32, n. 13, p. 3217-3225, APR 5 2016.
Citações Web of Science: 36
Resumo

The selective action of drugs in tumor cells is a major problem in cancer therapy. Most chemotherapy drugs act nonspecifically and damage both cancer and healthy cells causing various side effects. In this study, the preparation of a selective drug delivery system, which is able to act as a carrier for hydrophobic and anticancer drugs is reported. Amino-functionalized silica nanoparticles loaded with curcumin were successfully synthesized via sol-gel approach and duly characterized. Thereafter, the targeting ligand, folate, was covalently attached to amino groups of nanoparticle surface through amide bond formation. The cytotoxic effect of nanoparticles on prostate cancer cells line was evaluated and compared to normal cells line (prostate epithelial cell). Cytotoxicity experiments demonstrated that folate-functionalized nanoparticles were significantly cytotoxic to tumor cells, whereas normal cells were much less affected by the presence of these structures. (AU)

Processo FAPESP: 14/22322-2 - Funcionalização de nanopartículas de sílica: aumentando a interação biológica
Beneficiário:Mateus Borba Cardoso
Modalidade de apoio: Auxílio à Pesquisa - Regular