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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Clinical, behavioral and antinociceptive effects of crotalphine in horses

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Autor(es):
Bueno do Prado Guirro, Erica Cristina [1] ; Perotta, Joao Henrique [2] ; de Paula, Marcio [3] ; Cury, Yara [4] ; Araujo Valadao, Carlos Augusto [5]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Fed Parana UFPR, Dept Ciencias Vet, Setor Palotina, Rua Pioneiro 2153, BR-85950000 Palotina, PR - Brazil
[2] Univ Fed Parana UFPR, Dept Med Vet, Setor Agr, BR-85950000 Palotina, PR - Brazil
[3] Consorcio Ind Farmaceut COINFAR, Sao Paulo, SP - Brazil
[4] Inst Butantan, Lab Patofisiol, Sao Paulo, SP - Brazil
[5] Univ Estadual Paulista UNESP, Dept Clin & Cirurgia Vet, Jaboticabal, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Ciência Rural; v. 46, n. 4, p. 694-699, APR 2016.
Citações Web of Science: 0
Resumo

Crotalphine is a novel analgesic peptide that acts on kappa opioid and delta receptors, causing powerful analgesia in rats submitted to inflammatory, neuropathic or oncologic models of pain. This study evaluated clinical, behavioral and antinociceptive effects caused by crotalphine in horses, employing 18 Arabian horses and it was divided in three phases. In Phase I, ``clinical and behavioral effects{''}, crotalphine did not change the latency to urinate and defecate; did not modify the values of cardiac or respiratory rates, intestinal motility and rectal temperature; and did not cause significant ataxia, head, eye and lip ptosis. In Phase II, ``antinociceptive effect on intact skin at scapular or ischial region{''}, crotalphine did not cause significant analgesia. In Phase III, ``antinociceptive effect on incised skin at scapular or ischial region{''}, crotalphine promoted effective antinociceptive effects for six hours and inhibited hyperalgesia state for three days in the ischial region of horses submitted to incisional model of inflammatory pain, but crotalphine did not evoke relevant analgesic effect on the scapular region. Concluding, intravenous injection of a single dose of crotalphine (3.8ngkg(-1)) did not cause important clinical or behavioral changes and promotes antinociceptive effect on incised ischial region for seven days in horses. Moreover, crotalphine did not evoke relevant anti nociceptive effect on the scapular region or in intact skin of horses. (AU)

Processo FAPESP: 05/04480-0 - Avaliação dos efeitos comportamental, clínico e antinociceptivo do fator sintético CNF021.03 obtido a partir do veneno de serpentes Crotalus durissus terrificus, em eqüinos: comparação com morfina, U50-488H e fenilbutazona
Beneficiário:Carlos Augusto Araújo Valadão
Linha de fomento: Auxílio à Pesquisa - Regular