Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Orexin in the toad Rhinella schneideri: The location of orexinergic neurons and the role of orexin in ventilatory responses to hypercarbia and hypoxia

Texto completo
Autor(es):
Fonseca, Elisa M. [1] ; Dias, Mirela B. [2] ; Bicego, Kenia C. [1] ; Gargaglioni, Luciane H. [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, FCAV, Dept Anim Morphol & Physiol, Jaboticabal, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Biosci, Dept Physiol, Jaboticabal, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Respiratory Physiology & Neurobiology; v. 224, n. SI, p. 90-99, APR 2016.
Citações Web of Science: 4
Resumo

Recent reports have suggested that orexins, also known as hypocretins, play an important role in the modulation of respiratory control in mammals, but there are no data available describing the role of the orexinergic system in the peripheral and central chemoreception of non-mammalian vertebrates. Therefore, the present study was designed to examine the localization of orexin-immunoreactive neurons in the brain of toads (Rhinella schneideri) and to investigate the contribution of orexin receptor-1 (0X(1)R) to the hypoxic and hypercarbic ventilatory responses of these animals during light and dark phases. Our results demonstrated that the orexinergic neurons of R. schneideri are located in the suprachiasmatic nucleus of the diencephalon. Additionally, the intracerebroventricular injection of SB-334867 (OX1R selective antagonist) attenuated the ventilatory response to hypercarbia during the dark phase by acting on tidal volume and breathing frequency, while during the light phase, SB-334867 attenuated the ventilatory response to hypoxia by acting on tidal volume only. We conclude that in the toad R. schneideri, orexinergic neurons are located in the suprachiasmatic nucleus and that OX1R contributes to hypercarbic and hypoxic chemoreflexes. (C) 2014 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 08/57712-4 - Instituto Nacional de Pesquisas em Fisiologia Comparada
Beneficiário:Augusto Shinya Abe
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 12/19966-0 - Padrão cardiorrespiratório e ciclo sono-vigília de ratos e ratas expostos à fluoxetina durante o período prenatal
Beneficiário:Luciane Helena Gargaglioni Batalhão
Linha de fomento: Auxílio à Pesquisa - Regular