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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Beneficial Effects of Physical Exercise on Functional Capacity and Skeletal Muscle Oxidative Stress in Rats with Aortic Stenosis-Induced Heart Failure

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Autor(es):
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Gomes, Mariana Janini [1] ; Martinez, Paula Felippe [1] ; Salome Campos, Dijon Henrique [1] ; Pagan, Luana Urbano [1] ; Bonomo, Camila [1] ; Ruiz Lima, Aline Regina [1] ; Damatto, Ricardo Luiz [1] ; Cezar, Marcelo D. M. [1] ; Damatto, Felipe Cezar [1] ; Rosa, Camila Moreno [1] ; Garcia, Camila Marchiolli [1] ; Abreu Reyes, David Rafael [1] ; Henrique Fernandes, Ana Angelica [2] ; Fernandes, Denise Castro [3] ; Laurindo, Francisco Rafael [3] ; Okoshi, Katashi [1] ; Okoshi, Marina Politi [1]
Número total de Autores: 17
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, Botucatu, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Biosci Botucatu, Botucatu, SP - Brazil
[3] Univ Sao Paulo, Sch Med, Inst Heart, Sao Paulo, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY; 2016.
Citações Web of Science: 22
Resumo

Objective. We evaluated the influence of exercise on functional capacity, cardiac remodeling, and skeletal muscle oxidative stress, MAPK, and NF-kappa B pathway in rats with aortic stenosis-(AS-) induced heart failure (HF). Methods and Results. Eighteen weeks after AS induction, rats were assigned into sedentary control (C-Sed), exercised control (C-Ex), sedentary AS (AS-Sed), and exercised AS (AS-Ex) groups. Exercise was performed on treadmill for eight weeks. Statistical analyses were performed with Goodman and ANOVA or Mann-Whitney. HF features frequency and mortality did not differ between AS groups. Exercise improved functional capacity, assessed by maximal exercise test on treadmill, without changing echocardiographic parameters. Soleus cross-sectional areas did not differ between groups. Lipid hydroperoxide concentration was higher in AS-Sed than C-Sed and AS-Ex. Activity of antioxidant enzymes superoxide dismutase and glutathione peroxidase was changed in AS-Sed and restored in AS-Ex. NADPH oxidase activity and gene expression of its subunits did not differ between AS groups. Total ROS generation was lower in AS-Ex than C-Ex. Exercise modulated MAPK in AS-Ex and did not change NF-kappa B pathway proteins. Conclusion. Exercise improves functional capacity in rats with AS-induced HF regardless of echocardiographic parameter changes. In soleus, exercise reduces oxidative stress, preserves antioxidant enzyme activity, and modulates MAPK expression. (AU)

Processo FAPESP: 12/21687-1 - Influência da N-acetilcisteína sobre a sinalização de apoptose na musculatura esquelética de ratos com insuficiência cardíaca crônica
Beneficiário:Marina Politi Okoshi
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/22485-3 - Influência do exercício físico sobre o estresse oxidativo, as MAPK e o NF-ºB no músculo sóleo de ratos com insuficiência cardíaca induzida por estenose aórtica
Beneficiário:Mariana Janini Gomes
Linha de fomento: Bolsas no Brasil - Mestrado