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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

yy Contribution of inflammasome genetics in Plasmodium vivax malaria

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Autor(es):
Santos, Marina L. S. [1] ; Reis, Edione Cristina [2] ; Bricher, Pamela N. [2] ; Sousa, Tais N. [1] ; Brito, Cristiana F. A. [1] ; Lacerda, Marcus V. G. [3] ; Fontes, Cor J. F. [4] ; Carvalho, Luzia H. [1] ; Pontillo, Alessandra [2]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Fundacao Oswaldo Cruz, Ctr Pesquisas Rene Rachou, Lab Malaria, Belo Horizonte, MG - Brazil
[2] Univ Sao Paulo, Lab Imunogenet, Dept Imunol, Inst Ciencias Biomed, Ave Prof Lineu Prestes, 1730, Cidade Univ, Sao Paulo, SP - Brazil
[3] Fundacao Oswaldo Cruz, Fundacao Med Trop Dr Heitor Vieira Dourado, Inst Pesquisas Leonidas & Maria Deane, Manaus, Amazonas - Brazil
[4] Univ Fed Mato Grosso, Hosp Julio Muller, Cuiaba, MT - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: INFECTION GENETICS AND EVOLUTION; v. 40, p. 162-166, JUN 2016.
Citações Web of Science: 6
Resumo

Recent reports showed that, in mice, symptomatic Plasmodium infection triggers NLRP3/NLRP12-dependent inflammasome formation and caspase-1 activation in monocytes. In humans, few works demonstrated that inflammasome is activated in malaria. As Plasmodium vivax is a potent inducer of inflammatory response we hypothesised that inflammasome genetics might affect P. vivax malaria clinical presentation. For this purpose, selected SNPs in inflammasome genes were analysed among patients with symptomatic P. vivax malaria. 157 Brazilian Amazon patients with P. vivax malaria were genotyped for 10 single nucleotide polymorphisms (SNPs) in inflammasome genes NLRP1, NLRP3, AIM2, CARD8, IL1B, IL18 and MEFV. Effect of SNPs on hematologic and clinical parameters was analysed by multivariate analysis. Our data suggested an important role of NLRP1 inflammasome receptor in shaping the clinical presentation of P. vivax malaria, in term of presence of fever, anaemia and thrombocytopenia. Moreover IL1B rs1143634 resulted significantly associated to patients' parasitaemia, while IL18 rs5744256 plays a protective role against the development of anaemia. Polymorphisms in inflammasome genes could affect one or other aspects of malaria pathogenesis. Moreover, these data reveal novel aspects of P. vivax/host interaction that involved NLRP1-inflammasome. (c) 2016 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 13/06142-1 - Perfil genômico da resposta imune ao HIV-1 e implicações para a vacina terapêutica com células dendríticas contra o HIV-1
Beneficiário:Alessandra Pontillo
Linha de fomento: Auxílio à Pesquisa - Regular