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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Postnatal Development of Mongolian Gerbil Female Prostate: An Immunohistochemical and 3D Modeling Study

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Autor(es):
Sanches, Bruno D. A. [1] ; Zani, Bruno C. [2] ; Maldarine, Juliana S. [2] ; Biancardi, Manoel F. [3] ; Santos, Fernanda C. A. [3] ; Goes, Rejane M. [2] ; Vilamaior, Patricia S. L. [2] ; Taboga, Sebastiao R. [2]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Dept Struct & Funct Biol, Ave Bertrand Russel S-N, Campinas, SP - Brazil
[2] Univ Estadual Paulista UNESP, Dept Biol, Lab Microscopy & Microanal, Rua Cristovao Colombo, Sao Jose Do Rio Preto, SP - Brazil
[3] Univ Fed Goias, Dept Morphol, Samambaia 2, Goiania, Go - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: MICROSCOPY RESEARCH AND TECHNIQUE; v. 79, n. 5, p. 438-446, MAY 2016.
Citações Web of Science: 5
Resumo

The development of the prostate in male rodents, which involves complex epithelial-mesenchymal interactions between the urogenital sinus epithelium (UGE) and the urogenital sinus mesenchyme (UGM), has been deeply studied. In females, however, this process is not very clear. In this study, the postnatal development of the prostate in female Mongolian gerbils employing three-dimensional (3D) reconstructions, histochemical, and immunohistochemical techniques was characterized. It was observed that prostatic branching and differentiation in females was induced by a single mesenchyme localized at a ventrolateral position, which was named as ventrolateral mesenchyme (VLM); furthermore, the canalization of solid buds began on the third postnatal day (P3) and the branching morphogenesis on P5. We observed secretions in the acini at the end of the first month, and, on P45, the acini were completely differentiated. The strong cell proliferation phase in the first week coincided with the mesenchymal expression of estrogen receptor 1 (ESR1). The expression of androgen receptor (AR) paralleled cell differentiation, and, on P30, immunolabelling with p63 was restricted to basal cells. This study serves as a baseline parameter for future research on disruptions that could affect the development of the female prostate. (C) 2016 Wiley Periodicals, Inc. (AU)

Processo FAPESP: 13/16443-9 - Estudo descritivo do processo de ramificação do lobo ventral da próstata do Gerbilo da Mongólia (Meriones Unguiculatus)
Beneficiário:Bruno Casagrande Zani
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 13/15939-0 - Avaliação da exposição estrogênica intra-uterina sobre as principais vias de interações epitélio-mesenquimais envolvidas na morfogênese das ramificações do lobo ventral da próstata do Gerbilo da Mongólia (Meriones unguiculatus)
Beneficiário:Bruno Domingos Azevedo Sanches
Linha de fomento: Bolsas no Brasil - Doutorado Direto