Compounds of Anthostomella brabeji, an Endophytic Fungus Isolated from Paepalanthus planifolius (Eriocaulaceae)

Autor(es)

de Amorim, Marcelo R. ^[1] ; Somensi, Andressa ^[1] ; Araujo, Angela R. ^[1] ; Bonifacio, Bruna V. ^[2] ; Bauab, Tais M. ^[2] ; dos Santos, Lourdes C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista UNESP, Dept Quim Organ, Inst Quim, BR-14800900 Araraquara, SP - Brazil

^[2] Univ Estadual Paulista UNESP, Dept Ciencias Biol, Escola Ciencias Farmaceut, BR-14800900 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 27, n. 6, p. 1048-1054, JUN 2016.
• Citações Web of Science: 0

Resumo

In this study, fifteen endophytic fungi were isolated from Paepalanthus planifolius (Eriocaulaceae). From the capitula, seven endophytes were screened and evaluated for their metabolomic profile and radical scavenging activity (2,2-diphenyl-1-picrylhydrazyl (DPPH) assay). Chemical investigation of ethyl acetate extract of the endophytic fungus Anthostomella brabeji resulted in the isolation of one new compound, (+)-(6R*,7S*,8R*)-6,7,8-trihydroxy-2,2-dimethyl-5,6,7,8-tetrahydro-chroman-4-one, and three known compounds: 6-hydroxy-2,2-dimethyl-5,6,7,8-tetrahydro-7,8-epoxycroman-4-one, siccayne and eutypinol. All of the compound structures were elucidated using 1D and 2D nuclear magnetic resonance (NMR) and mass spectrometry (MS) analyses. The antimicrobial activity of the compounds and A. brabeji extract were assayed against the microorganisms Staphylococcus aureus, Escherichia coli, Salmonella setubal and Candida albicans. Measured minimal inhibitory concentration (MIC) values ranged from 31.25 to 1000.0 µg mL-1. (AU)

• Processo FAPESP: 15/04899-3 - Estudo químico dos extratos produzidos por fungos endofíticos associados às partes aéreas de espécies de Eriocaulaceae e sua atividade antimicrobiana
• Beneficiário: Lourdes Campaner dos Santos
• Modalidade de apoio: Auxílio à Pesquisa - Regular