Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effect of Aluminum Ion Incorporation on the Bioactivity and Structure in Mesoporous Bioactive Glasses

Texto completo
Autor(es):
Melchers, S. [1] ; Uesbeck, T. [1] ; Winter, O. [1, 2] ; Eckert, H. [1, 3] ; Eder, D. [1, 2]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Munster, Inst Phys Chem, Corrensstr 28-30, D-48149 Munster - Germany
[2] Vienna Univ Technol, Inst Mat Chem, Getreidemkt 9-BC-02, A-1060 Vienna - Austria
[3] Univ Sao Paulo, Inst Fis Sao Carlos, CEP 369, BR-13560590 Sao Carlos, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Chemistry of Materials; v. 28, n. 10, p. 3254-3264, MAY 24 2016.
Citações Web of Science: 9
Resumo

work is dedicated to biokinetic and structural investigations of Al2O3 doping (0.5 to 15 mol %) in ordered mesoporous bioactive glasses (MBGs), based on the composition 80% SiO2-15% CaO-5% P2O5 (in mol %). The synthesis was performed with the sol gel method in combination with a structure directing agent (P-123) for the formation of mesopores. Structural investigations reveal that the incorporation of additional Al2O3 in a range of 1 to 10 mol % reduces the order of the mesostructure, whereas doping with 15 mol % Al2O3 creates well ordered mesopores again. Nitrogen adsorption-desorption isotherms show that specific surface area, pore volume, and pore diameter decrease only slightly upon incorporation of Al2O3. In vitro bioactivity tests exhibit a small decrease in bioactivity upon incorporation of small amounts and a sudden drop beyond 3 mol %. This can be related to the strong interaction of Al3+ and PO43-, which could be proven by multinuclear single and double resonance solid state nuclear magnetic resonance (NMR) spectroscopy. The number of P-O-Al linkages has been estimated by Al-27(P-31) rotational echo double resonance (REDOR) experiments. The interaction of Al3+ and PO43- and the trapping of Ca2+ required for charge compensation hamper the release of P, Ca, and Si ions and thus provide less PO43- and Ca2+ ions for the crucial formation of hydroxycarbonate apatite (HCA). (AU)

Processo FAPESP: 13/07793-6 - CEPIV - Centro de Ensino, Pesquisa e Inovação em Vidros
Beneficiário:Edgar Dutra Zanotto
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs