| Texto completo | |
| Autor(es): |
Macedo, C. G.
[1]
;
Napimoga, M. H.
[2]
;
Rocha-Neto, L. M.
[1]
;
Abdalla, H. B.
[1]
;
Clemente-Napimoga, J. T.
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Campinas UNICAMP, Piracicaba Dent Sch, Dept Physiol Sci, Lab Orofacial Pain, Av Limeira 901, BR-13414903 Piracicaba, SP - Brazil
[2] Rio Leopoldo Mand Inst & Res Ctr, Lab Immunol & Mol Biol, Rua Jose Rocha Junqueira 13, BR-13045755 Campinas, SP - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS; v. 110, p. 27-34, JUL 2016. |
| Citações Web of Science: | 4 |
| Resumo | |
We have previously demonstrated that peripheral administration of 15d-PGJ(2) in the Temporomandibular joint (TMJ) of rats can prevent nociceptor sensitization, mediated by peroxisome proliferator activated receptor-gamma (PPAR-gamma), and kappa- and delta- opioid receptors. However, the mechanism that underlies the signaling of PPAR-gamma (upon activation by 15d-PGJ(2)) to induce antinociception, and how the opioid receptors are activated via 15d-PGJ(2) are not fully understood. This study demonstrates that peripheral antinociceptive effect of 15d-PGJ(2) is mediated by PPAR-gamma expressed in the inflammatory cells of TMJ tissues. Once activated by 15d-PGJ(2), PPAR-gamma induces the release of beta-endorphin and dynorphin, which activates kappa- and delta-opioid receptors in primary sensory neurons to induce the antinociceptive effect. (C) 2016 Elsevier Ltd. All rights reserved. (AU) | |
| Processo FAPESP: | 11/00683-5 - Avaliação do efeito periférico da 15d-PGJ2 no processo inflamatório induzido pela artrite reumatóide na articulação temporomandibular de ratos |
| Beneficiário: | Juliana Trindade Clemente Napimoga |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |