Anthocyanins as inflammatory modulators and the role of the gut microbiota

Autor(es)

Morais, Carina Almeida ^[1] ; de Rosso, Veridiana Vera ^[1] ; Estadella, Debora ^[1] ; Pisani, Luciana Pellegrini ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Inst Saude & Soc, Dept Biociencias, Santos, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF NUTRITIONAL BIOCHEMISTRY; v. 33, p. 1-7, JUL 2016.
• Citações Web of Science: 31

Resumo

The health benefits of consuming fruits that are rich in polyphenols, especially anthocyanins, have been the focus of recent in vitro and in vivo investigations. Thus, greater attention is being directed to the reduction of the inflammatory process associated with the intestinal microbiota and the mechanism underlying these effects because the microbiota has been closely associated with the metabolism of these compounds in the gastrointestinal tract. Further interest lies in the ability of these metabolites to modulate the growth of specific intestinal bacteria. Thus, this review examines studies involving the action of the anthocyanins that are present in many fruits and their effect in the modulating the inflammatory process associated with the interaction between the host and the gut microbiota. The findings of both in vitro and in vivo studies suggest a potential antiinflammatory effect of these compounds, which seem to inhibit activation of the signaling pathway mediated by the transcription factor NF kappa B. This effect is associated with modulation of a beneficial gut microbiota, particularly an increase in Bifidobacterium strains. (C) 2015 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 13/25101-4 - Efeito do extrato do fruto da palmeira juçara (Euterpe edulis Mart.) durante a gestação e lactação sobre os marcadores inflamatórios e proteína desacopladora 1 (UCP1) da prole aos 21 dias de vida
• Beneficiário: Luciana Pellegrini Pisani
• Modalidade de apoio: Auxílio à Pesquisa - Regular