Hepatitis E virus seroprevalence among schistosomiasis patients in Northeastern Brazil

Autor(es)

Passos-Castilho, Ana Maria ^[1] ; de Sena, Anne ^{[2, 1]} ; Coutinho Domingues, Ana Lucia ^[3] ; Lopes-Neto, Edmundo Pessoa ^[3] ; Medeiros, Tiberio Batista ^[3] ; Hernandez Granato, Celso Francisco ^{[2, 1]} ; Ferraz, Maria Lucia ^[4]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo Unifesp, Div Infect Dis, Sao Paulo, SP - Brazil

^[2] Fleury SA Grp, Sao Paulo - Brazil

^[3] Univ Fed Pernambuco UFPE, Div Gastroenterol, Recife, PE - Brazil

^[4] Univ Fed Sao Paulo Unifesp, Div Gastroenterol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Infectious Diseases; v. 20, n. 3, p. 262-266, MAY-JUN 2016.
• Citações Web of Science: 6

Resumo

Abstract Background Hepatitis E virus (HEV) can cause chronic infection with rapid progression to liver cirrhosis in immunocompromised patients. HEV seroprevalence in patients with Schistosoma mansoni in Brazil is unknown. We evaluated the prevalence of past or present HEV infection in schistosomiasis patients in Recife, Pernambuco, Brazil. A total of 80 patients with Schistosoma mansoni were consecutively enrolled in a cross-sectional study. Serum samples were tested for the presence of anti-HEV IgG antibodies by enzyme immunoassay (Wantai anti-HEV IgG, Beijing, China) and for the presence of HEV RNA using real time reverse transcriptase-polymerase chain reaction with primers targeting the HEV ORF2 and ORF3. Clinical and laboratory tests as well as abdominal ultrasound were performed at the same day of blood collection. Results Anti-HEV IgG was positive in 18.8% (15/80) of patients with SM. None of the samples tested positive for anti-HEV IgM or HEV-RNA. Patients with anti-HEV IgG positive presented higher levels of alanine aminotranferase (p = 0.048) and gama-glutamil transferase (p = 0.022) when compared to patients without anti-HEV IgG antibodies. Conclusion This study demonstrates that the seroprevalence of HEV is high in patients with Schistosoma mansoni in Northeastern of Brazil. Past HEV infection is associated with higher frequency of liver enzymes abnormalities. HEV infection and its role on the severity of liver disease should be further investigated among patients with Schistosoma mansoni. (AU)

• Processo FAPESP: 12/22925-3 - Infecção pelo vírus da hepatite e em pacientes imunocomprometidos: detecção, determinação da carga viral e caracterização molecular
• Beneficiário: Celso Francisco Hernandes Granato
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/03701-0 - Identificação de marcadores lipidômicos com potencial diagnóstico em carcinoma hepatocelular
• Beneficiário: Ana Maria Passos
• Modalidade de apoio: Bolsas no Brasil - Doutorado