Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Sleep restriction reduces the survival time and aggravates the neurological dysfunction and memory impairments in an animal model of cerebral hypoperfusion

Texto completo
Autor(es):
Kim, Lenise Jihe [1] ; Coelho, Fernando Morgadinho [1, 2] ; Araujo, Paula [1] ; Tedesco, Roberto Carlos [3] ; Souza, Rodrigo Barbosa [3] ; Tufik, Sergio [1] ; Andersen, Monica Levy [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Neurol & Neurocirurgia, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Morfol & Genet, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Brain Research; v. 1644, p. 213-221, AUG 1 2016.
Citações Web of Science: 0
Resumo

Cerebral blood flow is associated with the cerebrovascular prognosis. Sleep restriction (SR) may be a limiting factor of the prognosis after a cerebrovascular event, impairing the neurological recovery. We aimed to investigate the effects of SR on mortality rate and on behavioral and histological parameters of animals submitted to permanent cerebral hypoperfusion. Sixty male Wistar rats were distributed in 4 groups, according to the protocol of common carotid artery occlusion (CCAO) and SR: nSR+nCCAO, SR+nCCAO, nSR+CCAO, and SR+CCAO. The groups SR+nCCAO and SR+CCAO were submitted to SR during 10 days. The cerebral hypoperfusion was induced by the permanent CCAO. Neurological function and memory were assessed over 14 days of cerebral hypoperfusion. Analysis of neuropathological alterations were performed in the CA1 region of hippocampus. The mortality rate was 40% in the nSR+CCAO and SR+CCAO groups. SR significantly reduced the survival time of animals submitted to CCAO. After 7 and 14 days of cerebral hypoperfusion, 11% and 33% of the nSR+CCAO and SR+CCAO animals showed severe neurological dysfunction, respectively. A significant association between a high frequency of memory impairments with the group SR+CCAO was observed. The neuropathological alterations in CA1 region of hippocampus were similar among the groups. SR potentiates the negative effects of cerebral hypoperfusion conditions, suggesting that SR could be a factor associated with a worse prognosis after a cerebrovascular event. (C) 2016 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 13/14420-1 - Efeitos da restrição de sono em modelo animal de lesão cerebral isquêmica
Beneficiário:Lenise Jihe Kim
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 14/10255-9 - Ativação inflamatória induzida pela privação de sono: possível relação entre redução do tempo de sono e prejuízos no metabolismo lipídico
Beneficiário:Paula Cristina Alves Araújo
Linha de fomento: Bolsas no Brasil - Pós-Doutorado