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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Impaired executive functions in experimental model of temporal lobe epilepsy

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Autor(es):
Ramos, Fabiane Ochai [1, 2] ; Rodrigues Carreiro, Luiz Renato [1] ; Scorza, Fulvio Alexandre [2] ; Cysneiros, Roberta Monterazzo [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Presbiteriana Mackenzie, Lab Neurobiol, Programa Posgrad Disturbios Desenvolvimento, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Escola Paulista Med, Dept Neurol & Neurocirurgia, Sao Paulo, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Arquivos de Neuro-Psiquiatria; v. 74, n. 6, p. 470-477, JUN 2016.
Citações Web of Science: 2
Resumo

Objective: The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder (ADHD -like behavior in male Wistar rats with temporal lobe epilepsy (TLE). Method: Male Wistar rats at 25 day of age were submitted to animal model of TLE by pilocarpine injection (350 mg/kg, ip) and a control group received saline 0.9%. The animals were continuously video monitored up to the end of experiments. The behavioural tests (open field, elevated plus maze and operant conditioning box) started from 60 days postnatal. Results: Animals with TLE exhibited elevated locomotor activity, reduced level of anxiety-related behavior, impulsivity and impaired visuospatial working memory. Conclusion: Taken as a whole, we concluded that animals with TLE exhibited some cognitive and behavioural changes consistent with ADHD-like behavior. (AU)

Processo FAPESP: 11/50680-2 - Investigação multimodal da epileptogênese com ênfase na incorporação de novos modelos e novas ferramentas
Beneficiário:Iscia Teresinha Lopes Cendes
Linha de fomento: Auxílio à Pesquisa - Temático